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Product Details
H00004487-M11
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
1E2
Immunogen
MSX1 (NP_002439, 216 a.a. approximately 297 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: NRRAKAKRLQ EAELEKLKMA AKPMLPPAAF GLSFPLGGPA AVAAAAGASL YGASGPFQRA ALPVAPVGLY TAHVGYSMYH LT
Target Information
MSX1 is a member of the muscle segment homeobox gene family. It functions as a transcriptional repressor during embryogenesis through interactions with components of the core transcription complex and other homeoproteins. MSX1 may also have roles in limb-pattern formation, craniofacial development, particularly odontogenesis, and tumor growth inhibition. Mutations in the gene, which was once known as homeobox 7, have been associated with nonsyndromic cleft lip with or without cleft palate 5, Witkop syndrome, Wolf-Hirschom syndrome, and autosomoal dominant hypodontia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: homeo box, msh-like 1; homeobox 7; Homeobox protein Hox-7; Homeobox protein MSX-1; homeobox, msh-like 1; Hox-7.1; msh homeo box 1; Msh homeobox 1-like protein; msh homeobox homolog 1; muscle-segment homeobox
Gene Aliases: AA675338; AI324650; ECTD3; Hox-7; HOX7; Hox7.1; HYD1; msh; MSX1; STHAG1
UniProt ID: (Human) P28360, (Mouse) P13297
Entrez Gene ID: (Human) 4487, (Mouse) 17701
RNA polymerase II regulatory region sequence-specific DNA binding
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
p53 binding
DNA binding
protein binding
sequence-specific DNA binding
homeodomain transcription factor
negative regulation of transcription from RNA polymerase II promoter
cell morphogenesis
in utero embryonic development
epithelial to mesenchymal transition involved in endocardial cushion formation
transcription from RNA polymerase II promoter
muscle organ development
negative regulation of cell proliferation
anterior/posterior pattern specification
mesenchymal cell proliferation
signal transduction involved in regulation of gene expression
negative regulation of cell growth
positive regulation of BMP signaling pathway
forebrain development
midbrain development
protein localization to nucleus
embryonic forelimb morphogenesis
embryonic hindlimb morphogenesis
embryonic nail plate morphogenesis
middle ear morphogenesis
odontogenesis of dentin-containing tooth
regulation of odontogenesis
negative regulation of apoptotic process
positive regulation of DNA damage response, signal transduction by p53 class mediator
positive regulation of transcription from RNA polymerase II promoter
stem cell differentiation
protein stabilization
negative regulation of striated muscle cell differentiation
palate development
face morphogenesis
bone morphogenesis
cartilage morphogenesis
mammary gland epithelium development
BMP signaling pathway involved in heart development
activation of meiosis
positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator
negative regulation of transcription regulatory region DNA binding
positive regulation of mesenchymal cell apoptotic process
epithelial to mesenchymal transition
heart morphogenesis
transcription, DNA-templated
regulation of transcription, DNA-templated
multicellular organism development
heart development
embryonic limb morphogenesis
BMP signaling pathway
odontogenesis
embryonic digit morphogenesis
negative regulation of DNA binding
negative regulation of transcription, DNA-templated
cartilage development
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