Abnova

MSX2 Monoclonal Antibody (1F6)

View all (8) MSX2 antibodies

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MSX2 Antibody in Immunocytochemistry (ICC/IF) — Immunofluorescence of monoclonal antibody to MSX2 on HeLa cell. Antibody concentration is 10 µg/mL.

MSX2 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunoperoxidase of monoclonal antibody to MSX2 on formalin-fixed paraffin-embedded human testis. Antibody concentration is 1.5 µg/mL.

Product Details

H00004488-M04

Applications	Tested Dilution	Publications
Western Blot (WB)	1-5 µg/mL	-
Immunohistochemistry (Paraffin) (IHC (P))	1.5 µg/mL	-
ELISA (ELISA)	10 µg/mL	-

Product Specifications
Species Reactivity	Human
Host/Isotype	Mouse / IgG2a, kappa
Class	Monoclonal
Type	Antibody
Clone	1F6
Immunogen	MSX2 (NP_002440, 101 a.a. approximately 201 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. View immunogen
Conjugate	Unconjugated
Form	Liquid
Concentration	See Label
Purification	Affinity chromatography
Storage buffer	PBS, pH 7.4
Contains	no preservative
Storage conditions	-20° C, Avoid Freeze/Thaw Cycles

Product Specific Information

Sequence of this protein is as follows: TASVKSENSE DGAAWMQEPG RYSPPPRHMS PTTCTLRKHK TNRKPRTPFT TSQLLALERK FRQKQYLSIA ERAEFSSSLN LTETQVKIWF QNRRAKAKRL *

Target Information

Msx2 is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. This protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in the Msx2 gene are associated with parietal foramina 1 and craniosynostosis type 2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Homeobox protein Hox-8; Homeobox protein MSX-2; msh homeo box 2; msh homeobox homolog 2

Gene Aliases: CRS2; FPP; HOX8; MSH; MSX2; PFM; PFM1

UniProt ID: (Human) P35548

Entrez Gene ID: (Human) 4488

Molecular Function: homeodomain transcription factor

negative regulation of transcription from RNA polymerase II promoter osteoblast differentiation chondrocyte development osteoblast development outflow tract septum morphogenesis epithelial to mesenchymal transition involved in endocardial cushion formation endochondral bone growth transcription from RNA polymerase II promoter negative regulation of cell proliferation anterior/posterior pattern specification signal transduction involved in regulation of gene expression positive regulation of BMP signaling pathway negative regulation of CREB transcription factor activity embryonic forelimb morphogenesis embryonic hindlimb morphogenesis wound healing, spreading of epidermal cells embryonic nail plate morphogenesis negative regulation of apoptotic process negative regulation of fat cell differentiation negative regulation of keratinocyte differentiation positive regulation of osteoblast differentiation negative regulation of transcription, DNA-templated stem cell differentiation positive regulation of catagen bone trabecula formation cranial suture morphogenesis frontal suture morphogenesis branching involved in mammary gland duct morphogenesis BMP signaling pathway involved in heart development enamel mineralization cellular response to estradiol stimulus activation of meiosis negative regulation of transcription regulatory region DNA binding positive regulation of mesenchymal cell apoptotic process

Process(es)

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcription cofactor activity protein binding transcription factor binding sequence-specific DNA binding transcription regulatory region DNA binding