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|Tested species reactivity||Human, Rat|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Purified recombinant fragment of human MTHFR expressed in E. Coli.|
|Contains||0.03% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunohistochemistry (IHC)||1/200 - 1/1000|
|Western Blot (WB)||1/500 - 1/2000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-15844 targets MTHFR in IHC and WB applications and shows reactivity with Human and Rat samples.
The MA5-15844 immunogen is purified recombinant fragment of human MTHFR expressed in E. Coli. .
MA5-15844 detects MTHFR which has a predicted molecular weight of approximately 75kDa.
The protein encoded by this gene catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Genetic variation in this gene influences susceptibility to occlusive vascular disease, neural tube defects, colon cancer and acute leukemia, and mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
5,10-methylenetetrahydrofolate reductase (NADPH); methylenetetrahydrofolate reductase; RP11-56N19.4, 5,10-methylenetetrahydrofolate reductase (NADPH)