Invitrogen

MTNR1A Polyclonal Antibody

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MTNR1A Antibody in Western Blot (WB) — Western Blot staining of KELLY cell lysate using Product # PA5-19109 at a concentration of 0.3 µg/mL, the primary antibody incubation was 1 hour and the detection method was chemiluminescence.

Product Details

PA5-19109

Applications	Tested Dilution	Publications
Western Blot (WB)	1-3 µg/mL	View 1 publication 1 publication

Product Specifications
Species Reactivity	Rat
Published species	Pig
Host/Isotype	Goat / IgG
Class	Polyclonal
Type	Antibody
Immunogen	Synthetic peptide sequence (SLKYDKLYSSKNS) corresponding to the internal amino acids of MTNR1A View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.5 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	TBS, pH 7.3, with 0.5% BSA
Contains	0.02% sodium azide
Storage conditions	-20° C, Avoid Freeze/Thaw Cycles
RRID	AB_10979791

Product Specific Information

This antibody is predicted to react with bovine, canine and mouse based on sequence homology.

Target Information

This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Melatonin reduces intramuscular fat deposition by promoting lipolysis and increasing mitochondrial function.

Journal of lipid research

Liu K,Yu W,Wei W,Zhang X,Tian Y,Sherif M,Liu X,Dong C,Wu W,Zhang L,Chen J

PA5-19109 was used in Western Blotting to establish a link between melatonin signaling and lipid metabolism in mammalian models and suggest the potential for melatonin administration to treat or prevent obesity and related diseases.