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Invitrogen
MUSK Recombinant Rabbit Monoclonal Antibody (PSH05-68)
Advanced Verification
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 20
MUSK Antibody (MA5-52463) in ICC/IF
Immunofluorescence analysis of MUSK was performed using 70% confluent log phase L6 and RSC96 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 1 hour at room temperature. The cells were labeled with MUSK Recombinant Rabbit Monoclonal Antibody (PSH05-68) (Product # MA5-52463) at 1:100 dilution in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Donkey anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alex... View More
Product Details
MA5-52463
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
PSH05-68
Immunogen
Recombinant protein within human musk aa 1-516/869.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 40% glycerol, 0.1% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
Product Specific Information
Positive Control: Mouse skeletal muscle tissue lysate, rat skeletal muscle tissue lysate, human skeletal muscle tissue, mouse skeletal muscle tissue, rat skeletal muscle tissue.^M
^M
Sequence Similarities: 100% Mouse/Rat.^M
^M
Subcellular Location: Postsynaptic cell membrane.^M
^M
Predicted band size: 97 kDa.
Target Information
MUSK plays an important and selective role in many aspects of skeletal muscle development and function through the initial step of postsynaptic differentiation and formation of end-plate bands in cooperation with Rapsyn. Communication between cells is often mediated by receptors on the surface of the target cell that are triggered by specific ligands released by other cells. Receptor tyrosine kinase activity is strictly regulated by the binding of the appropriate ligand to the extracellular active site of the receptor. MuSK has been shown to be part of the agrin signaling complex and plays an important role in the development and architectural maintenance of the neuromuscular junction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC126323; MGC126324; muscle localized kinase 2; muscle specific kinase (neural fold/somite kinase 1); Muscle, skeletal receptor tyrosine protein kinase; Muscle, skeletal receptor tyrosine-protein kinase; muscle, skeletal, receptor tyrosine kinase; muscle-specific kinase receptor; muscle-specific protein kinase secretory isoform; muscle-specific tyrosine kinase receptor MuSK; Muscle-specific tyrosine protein kinase receptor; Muscle-specific tyrosine-protein kinase receptor; MuSK; RP23-170A3.1
Gene Aliases: CMS9; FADS; Mdk4; Mlk; MUSK; Nsk1; Nsk2; Nsk3
UniProt ID: (Human) O15146, (Mouse) Q61006, (Rat) Q62838
Entrez Gene ID: (Human) 4593, (Mouse) 18198, (Rat) 81725
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
protein binding
ATP binding
metal ion binding
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
protein kinase binding
PDZ domain binding
transmembrane signal receptor
positive regulation of protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
multicellular organism development
neuromuscular junction development
memory
regulation of synaptic growth at neuromuscular junction
positive regulation of gene expression
peptidyl-tyrosine phosphorylation
cell differentiation
protein autophosphorylation
skeletal muscle acetylcholine-gated channel clustering
positive regulation of protein geranylgeranylation
regulation of transcription, DNA-templated
protein phosphorylation
signal transduction
negative regulation of gene expression
phosphorylation
positive regulation of synaptic transmission, cholinergic
receptor clustering
positive regulation of neuron apoptotic process
positive regulation of synaptic growth at neuromuscular junction
positive regulation of peptidyl-tyrosine phosphorylation
response to electrical stimulus
long-term synaptic potentiation
response to muscle activity
response to axon injury
retina development in camera-type eye
cochlea development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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