MA5-13868 targets Major Vault Protein in FACS, GS, IHC (P), IP, and WB applications and shows reactivity with Human and Rat samples.
The MA5-13868 immunogen is proteins precipitated with AER317 from the phosphocellulose column flow through of extract of human breast cancer MCF-7 cells.
Major vault protein (MVP) is identical to lung-resistance related protein (LRP). Its shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to progesterone and glucocorticoid receptors are also able to co-immunoprecipitate the MVP. Reportedly, the lung-resistance related protein (LRP) is identical to human MVP. LRP is overexpressed in many neoplastic tissues and cell lines indicating a poor response to chemotherapy.
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Protein Aliases: Lung resistance-related protein; Major vault protein; MVP; testicular secretory protein Li 30
Gene Aliases: LRP; MVP; VAULT1