Immunogen sequence: HTTLGLLNKA KAHIKKLEEA ERKSQHQLEN LEREQRFLKW RLEQLQGPQE MERIRM
Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 98%.
Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: bHLHc11; Class C basic helix-loop-helix protein 11; MAD2; MAX dimerization protein 2; Max interactor 1; Max-interacting protein 1; Max-related transcription factor; MGC43220; MXD2; MXI; RP11-549L6.1
Gene Aliases: BHLHC11; MAD2; MXD2; MXI; MXI1
UniProt ID: (Human) P50539
Entrez Gene ID: (Human) 4601