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Proteintech
MYBBP1A Monoclonal Antibody (1H2D10), CoraLite® Plus 488
FIGURE: 1 / 1
MYBBP1A Antibody (CL488-67996) in Flow
1X10^6 HepG2 cells were intracellularly stained with 0.4 µg CoraLite® Plus 488 Anti-Human MYBBP1A (CL488-67996, Clone:1H2D10) (red), or 0.4 µg Control Antibody. Cells were fixed and permeabilized with Transcription Factor Staining Buffer Kit (PF00011).
Product Details
CL488-67996
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1H2D10
Immunogen
Recombinant protein
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Purification
Protein G
Storage buffer
PBS with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20° C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: STALSSFLTK RNSPLTVPMF LSLFSRHPVL CQSLLPILVQ HITGPVRPRR QACLLLQKTL SMREVRSCFE DPEWKQLMGQ VLAKVTENLR VLGEAQTKAQ HQQALSSLEL LNVLFRTCKH EKLTLDLTVL LGVLQGQQQS LQQGAHSTGS SRLHDLYWQA MKTLGVQRPK LEKKDAKEIP SATQSPISKK RKKKGFLPET KKRKKRKSED GTPAEDGTPA ATGGSQPPSM GRKKRNRTKA KVPAQANGTP TTKSPAPGAP TRSPSTPAKS PKLQKKNQKP SQVNGAPGSP TEPAGQKQHQ KALPKKGVLG KSPLSALARK KARLSLVIRS PSLLQSGAKK KAQVRKAGKP
Target Information
The Myb family of transcription factors, which includes the structurally related A-, B-, and c-Myb genes, regulate differentiation, cellular growth and transactivating gene expression. c-Myb plays an essential role in controlling the proliferation and differentiation of hematopoietic cells, cellular levels of c-Myb decreasing as cells reach terminal differentiation. Myb-binding protein 1A (MYBBP1A) is a novel nuclear protein localized predominantly, but not exclusively, in nucleoli. Although initially isolated as a c-Myb-interacting protein, MYBBP1A is expressed ubiquitously, and associates with a number of different transcription factors. MYBBP1A associates with the aromatic hydrocarbon receptor (AhR), enhancing transactivation and increasing AhR-dependent gene expression. MYBBP1A is a powerful negative regulator of PPAR gamma coactivator 1 alpha (PGC-1 alpha) by p38 MAPK and also acts as a nucleocytoplasmic shuttling protein that utilizes CRM1-dependent and independent nuclear export pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MYB binding protein 1a; MYB binding protein (P160) 1a; Myb-binding protein 1A; Myb-binding protein of 160 kDa; nuclear protein P160; p53-activated protein-2; PAR interacting protein; PAR-interacting protein; PIP
Gene Aliases: AL024407; AU019902; DBP; MYBBP1A; P160; p160MBP; p67MBP; PAP2
UniProt ID: (Human) Q9BQG0, (Rat) O35821, (Mouse) Q7TPV4
Entrez Gene ID: (Human) 10514, (Rat) 60571, (Mouse) 18432
osteoblast differentiation
transcription, DNA-templated
regulation of transcription, DNA-templated
nucleocytoplasmic transport
respiratory electron transport chain
circadian regulation of gene expression
cellular response to glucose starvation
positive regulation of gene expression, epigenetic
negative regulation of transcription, DNA-templated
positive regulation of cell cycle arrest
DNA biosynthetic process
intrinsic apoptotic signaling pathway by p53 class mediator
positive regulation of anoikis
rhythmic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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