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Invitrogen
MYH6/MYH7 Recombinant Rabbit Monoclonal Antibody (10J6U7)
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FIGURE: 1 / 6
MYH6/MYH7 Antibody (MA569546) in IHC (P)
Immunohistochemistry analysis of MYH6/MYH7 on paraffin-embedded Mouse heart tissue. Samples were incubated with MYH6/MYH7 recombinant monoclonal antibody (Product # MA569546) using a dilution of 1:800 (40x lens). Followed by a further incubation with Cy3 Goat Anti-Rabbit IgG (H+L) using a dilution of 1:500 (Red). DAPI was used for nuclear staining (Blue). High pressure antigen retrieval performed with 0. 01... View More
Product Details
MA569546
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
10J6U7
Immunogen
Synthetic peptide.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.32 mg/mL
Amount
132 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3., with 50% glycerol, 0.05% BSA
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Cardiac muscle myosin is a hexamer consisting of two heavy chain subunits, two light chain subunits, and two regulatory subunits. This gene encodes the alpha heavy chain subunit of cardiac myosin. The gene is located 4kb downstream of the gene encoding the beta heavy chain subunit of cardiac myosin. Mutations in this gene cause familial hypertrophic cardiomyopathy and atrial septal defect 3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha cardiac MHC; alpha myosin; alpha-myosin heavy chain; beta myosin heavy chain; beta-myosin heavy chain; cardiac muscle myosin heavy chain 7 beta; cardiac myosin heavy chain alpha isoform; cardiac myosin heavy chain beta isoform; cardiomyopathy, hypertrophic 1; MYH-beta/slow; MyHC-alpha; MyHC-beta; MyHC-slow; myosin 7; myosin heavy chain; Myosin heavy chain 6; Myosin heavy chain 7; myosin heavy chain beta-subunit; myosin heavy chain MYH7; muscle filament; myosin heavy chain polypeptide 6 cardiac muscle adult; myosin heavy chain polypeptide 7 cardiac muscle fetal; Myosin heavy chain slow isoform; Myosin heavy chain, cardiac muscle alpha isoform; Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha); Myosin heavy chain, cardiac muscle beta isoform; myosin heavy chain, cardiac muscle, adult; myosin heavy chain, cardiac muscle, fetal; myosin heavy chain, polypeptide 6, cardiac muscle, alpha; myosin heavy chain, polypeptide 7; myosin, heavy chain 7, cardiac muscle, beta; myosin, heavy polypeptide 6, cardiac muscle, alpha; myosin, heavy polypeptide 6, cardiac muscle, alpha (cardiomyopathy, hypertrophic 1); myosin, heavy polypeptide 7, cardiac muscle, beta; Myosin-6; Myosin-7; rhabdomyosarcoma antigen MU-RMS-40.7A; sarcomeric protein; unnamed protein product
Gene Aliases: A830009F23Rik; AA517445; alpha-MHC; ASD3; B-MHC; beta-MHC; CMD1EE; CMD1S; CMH1; CMH14; CMYO7A; CMYO7B; CMYP7A; CMYP7B; MPD1; MYH6; MYH7; MYHC; Myhc-a; Myhc-b; MyHC-I; MYHCA; MYHCB; SPMD; SPMM; SSS3
UniProt ID: (Human) P13533, (Human) P12883, (Mouse) Q02566, (Mouse) Q91Z83, (Rat) P02564
Entrez Gene ID: (Human) 4624, (Human) 4625, (Mouse) 17888, (Rat) 29556, (Mouse) 140781, (Rat) 29557
microfilament motor activity
nucleotide binding
motor activity
actin binding
calmodulin binding
ATP binding
myosin phosphatase activity
protein kinase binding
actin filament binding
protein binding
ATPase activity
actin-dependent ATPase activity
calcium-dependent ATPase activity
identical protein binding
protein homodimerization activity
protein heterodimerization activity
non-receptor serine/threonine protein kinase
in utero embryonic development
regulation of the force of heart contraction
regulation of heart rate
muscle system process
muscle contraction
striated muscle contraction
adult heart development
visceral muscle development
regulation of heart contraction
regulation of blood pressure
cardiac muscle hypertrophy in response to stress
actin filament-based movement
muscle filament sliding
myofibril assembly
sarcomere organization
ATP metabolic process
atrial cardiac muscle tissue morphogenesis
ventricular cardiac muscle tissue morphogenesis
cardiac muscle cell development
cardiac muscle contraction
regulation of heart growth
skeletal muscle contraction
regulation of the force of skeletal muscle contraction
transition between fast and slow fiber
regulation of slow-twitch skeletal muscle fiber contraction
metabolic process
BMP signaling pathway
regulation of ATPase activity
cardiac muscle fiber development
canonical Wnt signaling pathway
response to heat
response to reactive oxygen species
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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