MA5-15496 targets MYL2 in WB applications and shows reactivity with Human samples.
The MA5-15496 immunogen is purified recombinant fragment of MYL2 expressed in E. Coli.
MA5-15496 detects MYL2 which has a predicted molecular weight of approximately 19kDa.
Thus gene encodes the regulatory light chain associated with cardiac myosin beta heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy.
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Protein Aliases: Cardiac myosin light chain 2; cardiac myosin light chain-2; cardiac ventricular myosin light chain 2; CMH10; DKFZp779C0562; MLC-2; MLC-2s/v; MLC-2v; MLC2; MYL2; Myosin light chain 2, slow skeletal/ventricular muscle isoform; myosin light chain-2; Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; myosin, light chain 2, regulatory, cardiac, slow; myosin, light polypeptide 2, regulatory, cardiac, slow; regulatory light chain of myosin; RLC of myosin; slow cardiac myosin regulatory light chain 2; Ventricular myosin light chain 2
Gene Aliases: CMH10; Mlc-2; MLC-2s/v; MLC2; MYL2