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|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||An 18 amino acid peptide near the carboxy terminus of human MYOZAP.|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Immunocytochemistry (ICC)||20 ug/ml|
|Immunofluorescence (IF)||20 µg/ml|
|Immunohistochemistry (IHC)||5 µg/ml|
|Western Blot (WB)||1-2 ug/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
A suggested positive control is rat kidney tissue lysate.
PA5-21116 can be used with blocking peptide PEP-1230.
MYOZAP, also known as GRINL1A, is a 54 kDa highly conserved cardiac protein. It is strongly expressed in the heart and lung and is a novel component of intercalated disc. MYOZAP interacts with myosin phosphatase-RhoA interacting protein (MRIP) and acts as an activator of Rho-dependent SRF signaling. Knockdown study in zebrafish results in cardiomyopathy with severe dysfunction. The MYOZAP gene is part of a complex transcript unit that includes the gene for glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A (GRINL1A). Transcription of this gene occurs at an upstream promoter, with two different groups of alternatively spliced variants: Gup for GRINL1A upstream transcripts and Gcom for GRINL1A combined transcripts.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A combined protein; GRINL1A combined protein; GRINL1A combined protein Gcom12; GRINL1A complex locus 1; GRINL1A complex locus protein 1; GRINL1A, Gcom2, MYZAP-POLR2M, gcom; Myocardial zonula adherens protein; myozap; MYZAP-POLR2M protein; MYZAP-POLR2M readthrough; NMDAR1 subunit-interacting protein
AA407270; AV006038; gcom; Gcom1; Gcom2; Gm640; GRINL1A; Grinl1a7; Myozap; MYZAP; MYZAP-POLR2M