|Tested species reactivity||Human|
|Published species reactivity||Non-human primate, Human|
|Host / Isotype||Mouse / IgG2a, kappa|
|Immunogen||Recombinant protein corresponding to N-terminal region of human Maspin|
|Storage buffer||tissue culture supernatant|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:10-1:100|
|Western Blot (WB)||1:20-1:200|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-12383 targets Maspin in IHC (P) and WB applications and shows reactivity with human samples. In Western blot testing, this antibody did not cross-react with mouse samples.
The MA5-12383 immunogen is recombinant protein corresponding to N-terminal region of human Maspin.
Maspin or mammary-specific serpin is a tumor suppressor protein of serine proteinase inhibitor family. Its transcription is regulated in combinatorial fashion by Ets, p53 and AP-1. It is present in normal breast and prostatic epithelial cells but downregulated in the respective carcinomas. The extent of downregulation correlates with the progression of the carcinoma and may help in prognosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Expression of Snail transcription factor in prostatic adenocarcinoma in Egypt: correlation with Maspin protein expression and clinicopathologic variables.
MA5-12383 was used in immunohistochemistry to study the prognostic value of the immunohistochemical expression of Snail and mapsin in Egyptian prostate adenocarcinoma patients
|Fawzy AI,Gayyed MF,Elsaghir GA,Elbadry MS||International journal of clinical and experimental pathology (6:1558)||2013|
Expression of maspin in non-small cell lung cancer and its relationship to vasculogenic mimicry.
MA5-12383 was used in immunohistochemistry to study the significance of maspin expression in non-small cell lung cancer
|Wu S,Yu L,Cheng Z,Song W,Zhou L,Tao Y||Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban (32:346)||2012|
Proteomic characterization of ovarian cancers identifying annexin-A4, phosphoserine aminotransferase, cellular retinoic acid-binding protein 2, and serpin B5 as histology-specific biomarkers.
MA5-12383 was used in immunohistochemistry to use a proteomic approach to identify ANAX4, PSAT1, CRABP1 and SPB5 as biomarkers of specific histological sub-types of ovarian cancers
|Toyama A,Suzuki A,Shimada T,Aoki C,Aoki Y,Umino Y,Nakamura Y,Aoki D,Sato TA||Cancer science (103:747)||2012|
Maspin, VEGF and p53 expression in small biopsies of primary advanced lung cancer and relationship with clinicopathologic parameters.
MA5-12383 was used in immunohistochemistry to compare expression of Maspin, VEGF, and p53 between carcinomas
|Bircan A,Bircan S,Kapucuoglu N,Songur N,Ozturk O,Akkaya A||Pathology oncology research : POR (16:553)||2010|
Maspin expression in renal cell carcinoma and its correlation with clinicopathologic parameters.
MA5-12383 was used in immunohistochemistry to study the expression of maspin in renal cell carcinoma and its correlation with clinicopathologic parameters
|Turunc T,Bal N,Dirim A,Kuzgunbay B,Gul U,Ozkardes H||Urology (76:765.e8)||2010|
Maspin expression in gastrointestinal stromal tumors.
MA5-12383 was used in immunohistochemistry to investigate the distribution of maspin in gastrointestinal stromal tumors
|Adim SB,Filiz G,Kanat O,Yerci O,Ozguc H,Aytac B||World journal of surgical oncology (8:null)||2010|
Maspin, E-selectin, and P-selectin expressions in papillary thyroid carcinomas and their correlation with prognostic parameters.
MA5-12383 was used in immunohistochemistry to examine the prognostic significance of maspin, E-selectin, and P-selectin in papillary thyroid carcinomas
|Bal N,Kocer NE,Ertorer ME,Canpolat ET,Kayaselcuk F||Pathology, research and practice (204:743)||2008|
Maspin overexpression correlates with increased expression of vascular endothelial growth factors A, C, and D in human ovarian carcinoma.
MA5-12383 was used in immunohistochemistry to study the correlation of maspin expression with with that of VEGFA, VEGFC and VEGFD in human ovarian carcinoma
|Bolat F,Gumurdulu D,Erkanli S,Kayaselcuk F,Zeren H,Ali Vardar M,Kuscu E||Pathology, research and practice (204:379)||2008|
Simultaneous evaluation of maspin and CXCR4 in patients with breast cancer.
MA5-12383 was used in immunohistochemistry to study the expression of maspin and CXCR4 in breast tumors
|Tsoli E,Tsantoulis PK,Papalambros A,Perunovic B,England D,Rawlands DA,Reynolds GM,Vlachodimitropoulos D,Morgan SL,Spiliopoulou CA,Athanasiou T,Gorgoulis VG||Journal of clinical pathology (60:261)||2007|
Value of ezrin, maspin and nm23-H1 protein expressions in predicting outcome of patients with head and neck squamous-cell carcinoma treated with radical radiotherapy.
MA5-12383 was used in immunohistochemistry to study the prognostic value of ezrin, maspin and nm23-H1 in head and neck squamous-cell carcinoma treated with radical radiotherapy
|Mhawech-Fauceglia P,Dulguerov P,Beck A,Bonet M,Allal AS||Journal of clinical pathology (60:185)||2007|
Clinicopathological significance of maspin expression in breast cancer.
MA5-12383 was used in immunohistochemistry to study the expression of mapsin in invasive ductal carcinoma of the breast and the correlation with clinicopathological features
|Lee MJ,Suh CH,Li ZH||Journal of Korean medical science (21:309)||2006|
Maspin expression is directly associated with biological aggressiveness of thyroid carcinoma.
MA5-12383 was used in immunohistochemistry to study the association of maspin expression with biological aggressiveness of thyroid carcinoma
|Ito Y,Yoshida H,Tomoda C,Uruno T,Takamura Y,Miya A,Kobayashi K,Matsuzuka F,Matsuura N,Kuma K,Miyauchi A||Thyroid : official journal of the American Thyroid Association (14:13)||2004|
|Non-human primate||Not Cited||
A versatile monoclonal antibody specific to human SERPINB5.
MA5-12383 was used in western blot to characterize a novel monoclonal antibody against the serine protease inhibitor mapsin/SERPINB5
|Teoh SS,Wang H,Risbridger GP,Whisstock JC,Bird PI||Hybridoma (2005) (31:333)||2012|