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|Tested species reactivity||Human|
|Published species reactivity||Dog, Rat, Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Purified human skin chymase|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:2000|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-11717 targets Mast Cell Chymase in IHC (P) and WB applications and shows reactivity with Human samples.
The MA5-11717 immunogen is purified human skin chymase.
Mast cells contain a number of preformed chemical mediators such as histamine, chymase, carboxypeptidase and proteolytic tryptase. A substantial quantity of chymase is estimated to be found in mast cells of skin and lung and suggestes this enzyme plays a major role in mast cell mediated events. Human mast cell chymase is considered to be an important marker of mast cells as well as an important mediator of inflammation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
The role of macrophage migration inhibitory factor in mast cell-stimulated fibroblast proliferation and collagen production.
MA5-11717 was used in immunocytochemistry to develop a human mast cell culture system and study the effect of Macrophage Migration Inhibitory Factor supplementation
|Ningyan G,Xu Y,Hongfei S,Jingjing C,Min C||PloS one (10:null)||2015|
Hyperexpression of the high-affinity IgE receptor-beta chain in chronic allergic keratoconjunctivitis.
MA5-11717 was used in immunohistochemistry to investigate the expression of high-affinity IgE receptor-beta chain in vivo
|Matsuda A,Okayama Y,Ebihara N,Yokoi N,Hamuro J,Walls AF,Ra C,Hopkin JM,Kinoshita S||Investigative ophthalmology & visual science (50:2871)||2009|
Immediate anaphylactic death following antibiotics injection: splenic eosinophilia easily revealed by pagoda red stain.
MA5-11717 was used in immunohistochemistry to evaluate pagoda red stain for the forensic analysis of anaphylactic death
|Trani N,Bonetti LR,Gualandri G,Barbolini G||Forensic science international (181:21)||2008|
Identification of mast cells and mast cell subpopulations.
MA5-11717 was used in immunohistochemistry to discuss methods for the detection of mast cells and mast cell subpopulations
|Buckley M,Walls AF||Methods in molecular medicine (138:285)||2008|
Interstitial Cajal-like cells in rat mesentery: an ultrastructural and immunohistochemical approach.
MA5-11717 was used in immunohistochemistry to characterize the interstitial Cajal-like cells in rat mesentery
|Hinescu ME,Popescu LM,Gherghiceanu M,Faussone-Pellegrini MS||Journal of cellular and molecular medicine (12:260)||2008|
Insights into the interstitium of ventricular myocardium: interstitial Cajal-like cells (ICLC).
MA5-11717 was used in immunohistochemistry to investigate the presence and role of interstitial Cajal-like cells in atrial myocardium
|Popescu LM,Gherghiceanu M,Hinescu ME,Cretoiu D,Ceafalan L,Regalia T,Popescu AC,Ardeleanu C,Mandache E||Journal of cellular and molecular medicine (10:429)||2006|
Anti-CXCR3 staining is useful for detecting human cutaneous and mucosal mast cells.
MA5-11717 was used in immunohistochemistry to study anti-CXCR3 staining for detecting human cutaneous and mucosal mast cells
|Fukiwake N,Moroi Y,Imafuku S,Masuda T,Kokuba H,Furue M,Urabe K||The Journal of dermatology (33:326)||2006|
Immunohistochemical and histochemical stains for differentiating canine cutaneous round cell tumors.
MA5-11717 was used in immunohistochemistry to study histochemical and immunohistochemical stains for differentiating canine cutaneous round cell tumors
|Fernandez NJ,West KH,Jackson ML,Kidney BA||Veterinary pathology (42:437)||2005|
Cannabinoids reduce granuloma-associated angiogenesis in rats by controlling transcription and expression of mast cell protease-5.
MA5-11717 was used in western blot to examine the effect of cannabinoids on rodent granuloma-associated angiogenesis
|De Filippis D,Russo A,D'Amico A,Esposito G,Pietropaolo C,Concetta P,Cinelli M,Russo G,Iuvone T||British journal of pharmacology (154:1672)||2008|
alpha-chymase; chymase; chymase 1 preproprotein transcript E; chymase 1 preproprotein transcript I; chymase 1, mast cell; chymase, heart; chymase, mast cell; heart; mast cell; mast cell protease I
chymase; CMA1; CYH; CYM; MCT1