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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (KLH conjugated) to the extracellular N-terminus.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.7|
|Contains||0.01% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:200|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
OPA1-15011 detects MC4R from human samples.
OPA1-15011 has been successfully used in immunohistochemistry procedures. By immunohistochemistry, OPA1-15011 detects MC4R in formalin fixed, paraffin embedded human tissues.
The OPA1-15011 immunogen is a synthetic peptide (KLH conjugated) corresponding to the extracellular N-terminus. .
Melanocortin 4 receptor (MC4R), a Melanocortin Receptor, has been shown to affect food intake and energy balance. Recently MC4R has been shown to modulate erectile function and sexual behavior (Van Der Ploeg et al. 2002). Expression of MC4R has been reported in brain. Unlike the other melanocortin receptors, MC4R is not expressed in adrenal cortex or in melanocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
MC4-R; MC4R; Melanocortin receptor 4