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|Tested species reactivity||Human|
|Published species reactivity||Bovine, Mouse, Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||The extract of pigmented melanoma metastases from lymph nodes.|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Immunofluorescence (IF)||Assay dependent|
|Immunohistochemistry (Paraffin) (IHC (P))||Assay-dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-34759 detects Melanoma associated antigen from human samples.
MA1-34759 has been successfully used in immunofluorescence and Immunohistochemistry (paraffin) applications.
The MA1-34759 immunogen is the extract of pigmented melanoma metastases from lymph nodes.
Melanoma is a malignant tumor of melanocytes which are found predominantly in skin but also in the bowel and the eye (see uveal melanoma). It is one of the rarer types of skin cancer but causes the majority of skin cancer related deaths.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Targeting histone deacetylase 6 mediates a dual anti-melanoma effect: Enhanced antitumor immunity and impaired cell proliferation.
MA1-34759 was used in western blot to determine which HDAC to target to specifically inhibit metastatic melanoma
|Woan KV,Lienlaf M,Perez-Villaroel P,Lee C,Cheng F,Knox T,Woods DM,Barrios K,Powers J,Sahakian E,Wang HW,Canales J,Marante D,Smalley KS,Bergman J,Seto E,Kozikowski A,Pinilla-Ibarz J,Sarnaik A,Celis E,Weber J,Sotomayor EM,Villagra A||Molecular oncology (9:1447)||2015|
Mutations in or near the transmembrane domain alter PMEL amyloid formation from functional to pathogenic.
MA1-34759 was used in western blot to investigate the role of PMEL mutations in physiological and pathological amyloid fibril formation
|Watt B,Tenza D,Lemmon MA,Kerje S,Raposo G,Andersson L,Marks MS||PLoS genetics (7:null)||2011|
Cell-specific ATP7A transport sustains copper-dependent tyrosinase activity in melanosomes.
MA1-34759 was used in western blot to investigate the role of cell-specific ATP7A transport in copper-dependent tyrosinase activity of melanosomes
|Setty SR,Tenza D,Sviderskaya EV,Bennett DC,Raposo G,Marks MS||Nature (454:1142)||2008|
Melanocytes expressing MC1R polymorphisms associated with red hair color have altered MSH-ligand activated pigmentary responses in coculture with keratinocytes.
MA1-34759 was used in western blot to study the behavior and functional abilities of melanocytes expressing MC1R red hair color variants
|Roberts DW,Newton RA,Leonard JH,Sturm RA||Journal of cellular physiology (215:344)||2008|
Rab7 regulates maturation of melanosomal matrix protein gp100/Pmel17/Silv.
MA1-34759 was used in western blot to study the regulation of the melanosomal matrix protein gp100 by Rab7
|Kawakami A,Sakane F,Imai S,Yasuda S,Kai M,Kanoh H,Jin HY,Hirosaki K,Yamashita T,Fisher DE,Jimbow K||The Journal of investigative dermatology (128:143)||2008|
ASPL-TFE3 translocation in vulvovaginal alveolar soft part sarcoma.
MA1-34759 was used in immunohistochemistry to report on a case of vulvovaginal alveolar soft part sarcoma
|Jabbour MN,Seoud M,Al-Ahmadie H,Abdul-Karim FW,Zaatari GS||International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists (33:263)||2014|
Targeting BRAFV600E in an inducible murine model of melanoma.
MA1-34759 was used in immunohistochemistry to study the effects of targeting BRAF(V600E) on melanoma growth in an inducible murine model
|Hooijkaas AI,Gadiot J,van der Valk M,Mooi WJ,Blank CU||The American journal of pathology (181:785)||2012|
Genetic ablation of SOX18 function suppresses tumor lymphangiogenesis and metastasis of melanoma in mice.
MA1-34759 was used in immunohistochemistry to study the role of SOX18 function function in tumor lymphangiogenesis and metastasis of melanoma in mice
|Duong T,Proulx ST,Luciani P,Leroux JC,Detmar M,Koopman P,Francois M||Cancer research (72:3105)||2012|
Sporadic haemangioblastoma of the kidney with rhabdoid features and focal CD10 expression: report of a case and literature review.
MA1-34759 was used in immunohistochemistry to report on a case of sporadic haemangioblastoma of the kidney with rhabdoid features and focal CD10 expression
|Yin WH,Li J,Chan JK||Diagnostic pathology (7:null)||2012|
Effect of PUVA therapy on melanocytes and keratinocytes in non-segmental vitiligo: histopathological, immuno-histochemical and ultrastructural study.
MA1-34759 was used in immunohistochemistry to study the effects of PUVA treatment on melanocytes and keratinocytes from patients with non-segmental vitiligo
|Anbar TS,El-Sawy AE,Attia SK,Barakat MT,Moftah NH,El-Ammawy TS,Abdel-Rahman AT,El-Tonsy MH||Photodermatology, photoimmunology & photomedicine (28:17)||2012|
Primary myoepithelial carcinoma of the larynx: case report and review of the literature.
MA1-34759 was used in immunohistochemistry to report on a case of primary myoepithelial carcinoma of the larynx
|Yu G,Qu G,Kong L,Pan X,Wang W,Lv J||Pathology, research and practice (207:127)||2011|
Microscopic uterine lymphangioleiomyomatosis perivascular epithelioid cell neoplasm: a case report with the earliest manifestation of this enigmatic neoplasm.
MA1-34759 was used in immunohistochemistry to report a clinical case of microscopic lymphangioleiomyomatosis perivascular epithelioid cell neoplasm in uterus
|Clay MR,Gibson P,Lowell J,Cooper K||International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists (30:71)||2011|
Patterns of repigmentation in two cases of hypopigmented type of vitiligo.
MA1-34759 was used in immunohistochemistry to study patterns of repigmentation in two cases of hypopigmented type of vitiligo
|Anbar TS,El-Sawy AE,Attia SK,Moftah NH,El-Tonsy MH||Photodermatology, photoimmunology & photomedicine (25:156)||2009|
Pulmonary meningothelial-like nodules: new insights into a common but poorly understood entity.
MA1-34759 was used in immunohistochemistry to study pulmonary meningothelial-like nodules
|Mukhopadhyay S,El-Zammar OA,Katzenstein AL||The American journal of surgical pathology (33:487)||2009|
Vacuolar-type H(+)-ATPase with the a3 isoform is the proton pump on premature melanosomes.
MA1-34759 was used in immunohistochemistry to identify the proton pump on immature melanosomes as the vacuolar H(+)-ATPase a3 isoform
|Tabata H,Kawamura N,Sun-Wada GH,Wada Y||Cell and tissue research (332:447)||2008|
Cellular defects in Chediak-Higashi syndrome correlate with the molecular genotype and clinical phenotype.
MA1-34759 was used in immunohistochemistry to study the correlation between cellular defects, genotype and clinical phenotype in Chediak-Higashi syndrome
|Westbroek W,Adams D,Huizing M,Koshoffer A,Dorward H,Tinloy B,Parkes J,Helip-Wooley A,Kleta R,Tsilou E,Duvernay P,Digre KB,Creel DJ,White JG,Boissy RE,Gahl WA||The Journal of investigative dermatology (127:2674)||2007|
Characterization of t(6;11)(p21;q12) in a renal-cell carcinoma of an adult patient.
MA1-34759 was used in immunohistochemistry to report a clinical case of t(6;11)(p21;q12) renal-cell carcinoma
|Pecciarini L,Cangi MG,Lo Cunsolo C,Macri' E,Dal Cin E,Martignoni G,Doglioni C||Genes, chromosomes & cancer (46:419)||2007|
Accumulation of low-avidity anti-melanocortin receptor 1 (anti-MC1R) CD8+ T cells in the lesional skin of a patient with melanoma-related depigmentation.
MA1-34759 was used in immunohistochemistry to investigat specific CD8+ tissue-infiltrating T cells in a patient with melanoma
|Wankowicz-Kalinska A,Mailliard RB,Olson K,Graham F,Edington H,Kirkwood JM,Martinek S,Das PK,Storkus WJ||Melanoma research (16:165)||2006|
Differential recognition of a dileucine-based sorting signal by AP-1 and AP-3 reveals a requirement for both BLOC-1 and AP-3 in delivery of OCA2 to melanosomes.
MA1-34759 was used in immunocytochemistry to study the delivery of OCA2 to melanosomes and the distinct roles played by AP-1 and AP-3
|Sitaram A,Dennis MK,Chaudhuri R,De Jesus-Rojas W,Tenza D,Setty SR,Wood CS,Sviderskaya EV,Bennett DC,Raposo G,Bonifacino JS,Marks MS||Molecular biology of the cell (23:3178)||2012|
Cellular and clinical report of new Griscelli syndrome type III cases.
MA1-34759 was used in immunocytochemistry to report on new cases of Griscelli syndrome type III
|Westbroek W,Klar A,Cullinane AR,Ziegler SG,Hurvitz H,Ganem A,Wilson K,Dorward H,Huizing M,Tamimi H,Vainshtein I,Berkun Y,Lavie M,Gahl WA,Anikster Y||Pigment cell & melanoma research (25:47)||2012|
Endoscopic ultrasound-guided fine-needle aspiration of intrathoracic and intra-abdominal spindle cell and mesenchymal lesions.
MA1-34759 was used in immunocytochemistry to confirm the diagnostic value of endoscopic ultrasound-guided fine-needle aspiration
|Bean SM,Baker A,Eloubeidi M,Eltoum I,Jhala N,Crowe R,Jhala D,Chhieng DC||Cancer cytopathology (119:37)||2011|
Clinical and cellular characterisation of Hermansky-Pudlak syndrome type 6.
MA1-34759 was used in immunocytochemistry to study the clinical and cellular characteristics of Hermansky-Pudlak syndrome subtype 6
|Huizing M,Pederson B,Hess RA,Griffin A,Helip-Wooley A,Westbroek W,Dorward H,O'Brien KJ,Golas G,Tsilou E,White JG,Gahl WA||Journal of medical genetics (46:803)||2009|
A novel missense mutation (G43S) in the switch I region of Rab27A causing Griscelli syndrome.
MA1-34759 was used in immunocytochemistry to investigate the role of Rab27A specific mutation in Griscelli syndrome
|Westbroek W,Tuchman M,Tinloy B,De Wever O,Vilboux T,Hertz JM,Hasle H,Heilmann C,Helip-Wooley A,Kleta R,Gahl WA||Molecular genetics and metabolism (94:248)||2008|
Improper trafficking of melanocyte-specific proteins in Hermansky-Pudlak syndrome type-5.
MA1-34759 was used in immunocytochemistry to study the trafficking of melanocyte-specific proteins in Hermansky-Pudlak syndrome type-5 melanocytes
|Helip-Wooley A,Westbroek W,Dorward HM,Koshoffer A,Huizing M,Boissy RE,Gahl WA||The Journal of investigative dermatology (127:1471)||2007|
Dual loss of ER export and endocytic signals with altered melanosome morphology in the silver mutation of Pmel17.
MA1-34759 was used in immunocytochemistry to examine the mechanism for the coat hypopigmentation
|Theos AC,Berson JF,Theos SC,Herman KE,Harper DC,Tenza D,Sviderskaya EV,Lamoreux ML,Bennett DC,Raposo G,Marks MS||Molecular biology of the cell (17:3598)||2006|
A novel splice variant of Pmel17 expressed by human melanocytes and melanoma cells lacking some of the internal repeats.
MA1-34759 was used in immunocytochemistry to study the alternative splicing of Pmel17 in human melanocytes and melanoma cells
|Nichols SE,Harper DC,Berson JF,Marks MS||The Journal of investigative dermatology (121:821)||2003|
Proprotein convertase cleavage liberates a fibrillogenic fragment of a resident glycoprotein to initiate melanosome biogenesis.
MA1-34759 was used in immunocytochemistry to investigate the role of proprotein convertase cleavage in melanosome biogenesis
|Berson JF,Theos AC,Harper DC,Tenza D,Raposo G,Marks MS||The Journal of cell biology (161:521)||2003|
Mannose receptor targeting of tumor antigen pmel17 to human dendritic cells directs anti-melanoma T cell responses via multiple HLA molecules.
MA1-34759 was used in blocking or activating experiment to study the T cell immune response against melanoma elicited through conjugation of melanoma antigen with mannose receptor antibody
|Ramakrishna V,Treml JF,Vitale L,Connolly JE,O'Neill T,Smith PA,Jones CL,He LZ,Goldstein J,Wallace PK,Keler T,Endres MJ||Journal of immunology (Baltimore, Md. : 1950) (172:2845)||2004|
cell surface glycoprotein P1H12; Gicerin; melanoma adhesion molecule; melanoma-associated antigen A32; melanoma-associated antigen MUC18; S-endo 1 endothelial-associated antigen
CD146; MCAM; MUC18