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|Tested species reactivity||Human, Mouse|
|Host / Isotype||Mouse / IgG|
|Immunogen||Mouse Mist1, C-terminus residues 175-197.|
|Storage buffer||PBS with 1mg/ml BSA|
|Contains||0.05% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin, Frozen) (IHC (P, F))||Assay dependent|
|Western Blot (WB)||1:100-1:500|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-517 detects Mist1 from mouse and human samples.
MA1-517 has been successfully used in Western blot, immunohistochemistry procedures. The antibody reactivity in IP and ChIP is weaker than in other applications. By Western blot, MA1-517 detects a ~29 kDa band representing Mist1.
The MA1-517 immunogen is mouse Mist1, C-terminus residues 175-197.
Mist 1 plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E-box occupancy by homodimers. This protein also negatively regulates bHLH-mediated transcription through an N-terminal repressor domain, and serves as a key regulator of acinar cell function, stability, and identity.
Mist 1 is also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport, and may function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
basic helix-loop-helix domain containing, class B, 8; basic helix-loop-helix family, member a15; BHLHB8; class A basic helix-loop-helix protein 15; class B basic helix-loop-helix protein 8; class II bHLH protein MIST1; MIST-1; MIST1; muscle, intestine and stomach expression 1
1810009C13Rik; BHLHA15; BHLHB8; MIST-1; MIST1