Invitrogen

Moesin Monoclonal Antibody (38/87)

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Moesin Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Formalin-fixed, paraffin-embedded human placenta stained with Moesin antibody using peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of endothelial cells.

Moesin Antibody in Western Blot (WB) — Published figure using Moesin monoclonal antibody (Product # MA5-14043) in Western Blot

Product Details

MA5-14043

Applications	Tested Dilution	Publications
Western Blot (WB)	1-2 µg/mL	View 7 publications 7 publications
Immunohistochemistry (Paraffin) (IHC (P))	0.25-0.5 µg/mL	-
Immunoprecipitation (IP)	2 µg/mL	-
Immunohistochemistry (IHC)	-	View 7 publications 7 publications
Miscellaneous PubMed (Misc)	-	View 1 publication 1 publication
Flow Cytometry (Flow)	-	View 1 publication 1 publication
Immunocytochemistry (ICC/IF)	-	View 1 publication 1 publication

Product Specifications
Species Reactivity	Bovine, Human, Rat
Published species	Human, Mouse
Host/Isotype	Mouse / IgG1, kappa
Class	Monoclonal
Type	Antibody
Clone	38/87
Immunogen	Moesin purified from cow uterus
Conjugate	Unconjugated
Form	Liquid
Concentration	0.2 mg/mL
Purification	Protein G
Storage buffer	PBS, pH 7.4, with 0.2% BSA
Contains	0.09% sodium azide
Storage conditions	4° C
RRID	AB_10983113

Product Specific Information

MA5-14043 targets Moesin in IF, IHC (P), IP, and WB applications and shows reactivity with Bovine, Human, and Rat samples.

The MA5-14043 immunogen is moesin purified from cow uterus.

Target Information

Moesin, a member of the talin-4. 1 superfamily, is a linking protein of the submembraneous actin cytoskeleton. It is expressed in macrophages, lymphocytes, fibroblastic, endothelial, epithelial, and neuronal cell lines but not in blood cells. It is involved in cell adhesion, migration, and organization of cell surface structures.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Signal-dependent slow leukocyte rolling does not require cytoskeletal anchorage of P-selectin glycoprotein ligand-1 (PSGL-1) or integrin αLβ2.

The Journal of biological chemistry

Shao B,Yago T,Coghill PA,Klopocki AG,Mehta-D'souza P,Schmidtke DW,Rodgers W,McEver RP

MA5-14043 was used in western blot to study whether cytoskelatal-anchorage of PSGL-1 and alphaLbeta2 intergrin is required for signal-dependent slow leukocyte rolling

Fri Jun 01 00:00:00 EDT 2012

Signal-dependent slow leukocyte rolling does not require cytoskeletal anchorage of P-selectin glycoprotein ligand-1 (PSGL-1) or integrin αLβ2.

The Journal of biological chemistry

Shao B,Yago T,Coghill PA,Klopocki AG,Mehta-D'souza P,Schmidtke DW,Rodgers W,McEver RP

MA5-14043 was used in western blot to study whether cytoskelatal-anchorage of PSGL-1 and alphaLbeta2 intergrin is required for signal-dependent slow leukocyte rolling

Fri Jun 01 00:00:00 EDT 2012

Cytoplasmic ezrin and moesin correlate with poor survival in head and neck squamous cell carcinoma.

Head and neck pathology

Schlecht NF,Brandwein-Gensler M,Smith RV,Kawachi N,Broughel D,Lin J,Keller CE,Reynolds PA,Gunn-Moore FJ,Harris T,Childs G,Belbin TJ,Prystowsky MB

MA5-14043 was used in immunohistochemistry to study the prognostic value of cytoplasmic expression of ezrin and moesin in head and neck squamous cell carcinoma

Fri Jun 01 00:00:00 EDT 2012

The effect of sphingomyelin synthase 2 (SMS2) deficiency on the expression of drug transporters in mouse brain.

Biochemical pharmacology

Zhang Y,Dong J,Zhu X,Wang W,Yang Q

MA5-14043 was used in western blot to identify the relationship between sphingomyelin synthetase 2 levels and drug transporter expression

Mon Aug 01 00:00:00 EDT 2011

Distinct cellular and therapeutic effects of obatoclax in rituximab-sensitive and -resistant lymphomas.

British journal of haematology

Brem EA,Thudium K,Khubchandani S,Tsai PC,Olejniczak SH,Bhat S,Riaz W,Gu J,Iqbal A,Campagna R,Knight J,Mavis C,Hoskin P,Deeb G,Gibbs JF,Fetterly G,Czuczman MS,Hernandez-Ilizaliturri FJ

MA5-14043 was used in western blot to study the cellular and therapeutic effects of obatoclax in rituximab-sensitive and -resistant lymphomas

Wed Jun 01 00:00:00 EDT 2011

Distinct molecular mechanisms responsible for bortezomib-induced death of therapy-resistant versus -sensitive B-NHL cells.

Blood

Olejniczak SH,Blickwedehl J,Belicha-Villanueva A,Bangia N,Riaz W,Mavis C,Clements JL,Gibbs J,Hernandez-Ilizaliturri FJ,Czuczman MS

MA5-14043 was used in western blot to study the molecular mechanisms responsible for bortezomib-induced death of therapy-resistant versus -sensitive B-NHL cells

Thu Dec 16 00:00:00 EST 2010

Immunohistochemical profiling of node negative breast carcinomas allows prediction of metastatic risk.

International journal of oncology

Giusiano S,Secq V,Carcopino X,Carpentier S,Andrac L,Lavaut MN,Allasia C,Bonnier P,Iovanna JL,Garcia S,Boubli L,Birnbaum D,Charpin C

MA5-14043 was used in immunohistochemistry - paraffin section to identify a prognostic immunohistochemical signature indicative of risk of early metastasis in node-negative breast carcinomas and use this information to develop targeted therapies

Thu Apr 01 00:00:00 EDT 2010

TREM-like transcript-1 protects against inflammation-associated hemorrhage by facilitating platelet aggregation in mice and humans.

The Journal of clinical investigation

Washington AV,Gibot S,Acevedo I,Gattis J,Quigley L,Feltz R,De La Mota A,Schubert RL,Gomez-Rodriguez J,Cheng J,Dutra A,Pak E,Chertov O,Rivera L,Morales J,Lubkowski J,Hunter R,Schwartzberg PL,McVicar DW

MA5-14043 was used in western blot to investigate the protective effect of TREM-like transcript-1 -1 against inflammation-associated hemorrhage

Mon Jun 01 00:00:00 EDT 2009

Anti-moesin antibodies in the serum of patients with aplastic anemia stimulate peripheral blood mononuclear cells to secrete TNF-alpha and IFN-gamma.

Journal of immunology (Baltimore, Md. : 1950)

Takamatsu H,Espinoza JL,Lu X,Qi Z,Okawa K,Nakao S

MA5-14043 was used in flow cytometry to study the role of anti-moesin antibodies in the secretion of TNF-alpha and IFN-gamma by PBMCs in patients with aplastic anemia

Thu Jan 01 00:00:00 EST 2009

Acquired resistance to rituximab is associated with chemotherapy resistance resulting from decreased Bax and Bak expression.

Clinical cancer research : an official journal of the American Association for Cancer Research

Olejniczak SH,Hernandez-Ilizaliturri FJ,Clements JL,Czuczman MS

MA5-14043 was used in western blot to study the role of Bax and Bak downregulation in the drug resistance to rituximab

Sat Mar 01 00:00:00 EST 2008

Adhesion molecules as prognostic markers in pancreatic adenocarcinoma.

Journal of surgical oncology

Torer N,Kayaselcuk F,Nursal TZ,Yildirim S,Tarim A,Nòyan T,Karakayali H

MA5-14043 was used in immunohistochemistry to study the prognostic value of ezrin, radixin, moesin and E-cadherin in pancreatic ductal adenocarcinoma

Mon Oct 01 00:00:00 EDT 2007

Specific antibodies to moesin, a membrane-cytoskeleton linker protein, are frequently detected in patients with acquired aplastic anemia.

Blood

Takamatsu H,Feng X,Chuhjo T,Lu X,Sugimori C,Okawa K,Yamamoto M,Iseki S,Nakao S

MA5-14043 was used in western blot to identify novel auto-antibodies in acquired aplastic anemia

Thu Mar 15 00:00:00 EDT 2007

Differential tissue and subcellular expressionof ERM proteins in normal and malignant tissues: cytoplasmic ezrin expression has prognostic signficance for head and neck squamous cell carcinoma.

Head & neck

Madan R,Brandwein-Gensler M,Schlecht NF,Elias K,Gorbovitsky E,Belbin TJ,Mahmood R,Breining D,Qian H,Childs G,Locker J,Smith R,Haigentz M,Gunn-Moore F,Prystowsky MB

MA5-14043 was used in immunohistochemistry to examine the prognostic significance of cytoplasmic ezrin expression for head and neck squamous cell carcinoma

Wed Nov 01 00:00:00 EST 2006

Ezrin promotes ovarian carcinoma cell invasion and its retained expression predicts poor prognosis in ovarian carcinoma.

International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists

Köbel M,Gradhand E,Zeng K,Schmitt WD,Kriese K,Lantzsch T,Wolters M,Dittmer J,Strauss HG,Thomssen C,Hauptmann S

MA5-14043 was used in immunohistochemistry to study the role of ezrin in ovarian carcinoma cell invasion

Sat Apr 01 00:00:00 EST 2006

Ezrin is essential for epithelial organization and villus morphogenesis in the developing intestine.

Developmental cell

Saotome I,Curto M,McClatchey AI

MA5-14043 was used in immunohistochemistry to study the essential role of Ezrin in epithelial organization and villus morphogenesis during intestinal development

Tue Jun 01 00:00:00 EDT 2004

Chemokine stimulation of human peripheral blood T lymphocytes induces rapid dephosphorylation of ERM proteins, which facilitates loss of microvilli and polarization.

Blood

Brown MJ,Nijhara R,Hallam JA,Gignac M,Yamada KM,Erlandsen SL,Delon J,Kruhlak M,Shaw S

MA5-14043 was used in immunocytochemistry to investigate the regulation of chemokines on Carboxyphosphorylated-ERM and its effect on the morphology and activation of human peripheral blood T lymphocytes

Mon Dec 01 00:00:00 EST 2003

Molecular profiling of bladder cancer using cDNA microarrays: defining histogenesis and biological phenotypes.

Cancer research

Sanchez-Carbayo M,Socci ND,Charytonowicz E,Lu M,Prystowsky M,Childs G,Cordon-Cardo C

MA5-14043 was used in immunohistochemistry to study the molecular profile of bladder cancer using cDNA microarrays

Sun Dec 01 00:00:00 EST 2002

Ezrin and moesin expression within the developing human cerebrum and tuberous sclerosis-associated cortical tubers.

Acta neuropathologica

Johnson MW,Miyata H,Vinters HV

MA5-14043 was used in immunohistochemistry to study the expression of ezrin and moesin in developing human cerebrum and tuberous sclerosis-associated cortical tubers