STS1 and STS2 Phosphatase Inhibitor Baicalein Enhances the Expansion of Hematopoietic and Progenitor Stem Cells and Alleviates 5-Fluorouracil-Induced Myelosuppression.
International journal of molecular sciences
Li N,Wang Y,Wang A,Zhang J,Jia C,Yu C,Song Z,Wang S,Liu L,Yi J,Bao Y,Huang Y,Sun L
22-7770-72 was used in Flow cytometry/Cell sorting to suggest BC as one of the small molecule candidates to stimulate HSPC expansion both in vitro and in vivo when needed in either physiologic or pathologic conditions, but also supports STS1/STS2 as potential therapeutic drug targets for HSPC expansion and hematopoietic injury recovery.
Fri Feb 03 00:00:00 EST 2023
Gasdermin D inhibition ameliorates neutrophil mediated brain damage in acute ischemic stroke.
Cell death discovery
Hu R,Liang J,Ding L,Zhang W,Wang Y,Zhang Y,Zhang D,Pei L,Liu X,Xia Z,Xu Y,Song B
22-7770-72 was used in Flow cytometry/Cell sorting to provide a new viewpoint on the immunological modulation of neutrophils after MCAO and suggest that suppression of GSDMD may relieve the neuroinflammatory load, thereby providing a potential treatment strategy for stroke.
Wed Feb 08 00:00:00 EST 2023
Gut Microbial Metabolite Pravastatin Attenuates Intestinal Ischemia/Reperfusion Injury Through Promoting IL-13 Release From Type II Innate Lymphoid Cells via IL-33/ST2 Signaling.
Frontiers in immunology
Deng F,Hu JJ,Yang X,Sun QS,Lin ZB,Zhao BC,Yao ZW,Luo SD,Chen ZL,Liu Y,Yan ZZ,Li C,Liu WF,Liu KX
22-7770-72 was used in Flow Cytometry to indicate that the gut microbial metabolite PA can attenuate intestinal I/R injury by promoting the release of IL-13 from ILC2s via IL-33/ST2 signaling.
Tue Dec 21 00:00:00 EST 2021
Type 2 Innate Lymphoid Cells Accumulate in the Brain After Hypoxia-Ischemia but Do Not Contribute to the Development of Preterm Brain Injury.
Frontiers in cellular neuroscience
Zelco A,Rocha-Ferreira E,Nazmi A,Ardalan M,Chumak T,Nilsson G,Hagberg H,Mallard C,Wang X
22-7770 was used in Flow cytometry/Cell sorting to investigate if innate lymphoid cells, especially ILC2s, play a role in preterm brain injury.
Sat Apr 16 00:00:00 EDT 2022
CD137 Signaling Regulates Acute Colitis via RALDH2-Expressing CD11b-CD103+ DCs.
Jin J,Jung IH,Moon SH,Jeon S,Jeong SJ,Sonn SK,Seo S,Lee MN,Song EJ,Kweon HY,Kim S,Kim TK,Kim J,Cho HR,Choi JH,Kwon B,Oh GT
22-7770 was used in Flow cytometry/Cell sorting to define a mechanism of paracrine immunoregulation operating between adjacent DC subsets in the intestine.
Tue Mar 24 00:00:00 EDT 2020
Manipulation of the tumor microenvironment by cytokine gene transfection enhances dendritic cell-based immunotherapy.
Wijesekera DPH,Yuba E,De Silva NH,Watanabe SI,Tsukamoto M,Ichida C,Izawa T,Itoh K,Kanegi R,Hatoya S,Yamate J,Inaba T,Sugiura K
22-7770-72 was used in Flow Cytometry to manipulate the microenvironment so as to elicit activation of T helper type 1 (Th1) responses and the maturation of dendritic cells (DCs).
Wed Jan 01 00:00:00 EST 2020
A Circular RNA Protects Dormant Hematopoietic Stem Cells from DNA Sensor cGAS-Mediated Exhaustion.
Xia P,Wang S,Ye B,Du Y,Li C,Xiong Z,Qu Y,Fan Z
22-7770 was used in Flow cytometry/Cell sorting to study circular RNA-mediated maintenance of hematopoeitic stem cell homeostasis.
Tue Apr 17 00:00:00 EDT 2018
Der f 31, a novel allergen from Dermatophagoides farinae, activates epithelial cells and enhances lung-resident group 2 innate lymphoid cells.
Wang H,Lin J,Zeng L,Ouyang C,Ran P,Yang P,Liu Z
22-7770 was used in Flow cytometry/Cell sorting to investigate whether Dermatophagoides farinae-31 modulates airway epithelial cell functions, and increases the frequency of lung-resident group 2 innate lymphoid cells.
Thu Aug 17 00:00:00 EDT 2017
Caloric Restriction Leads to Browning of White Adipose Tissue through Type 2 Immune Signaling.
Fabbiano S,Suárez-Zamorano N,Rigo D,Veyrat-Durebex C,Stevanovic Dokic A,Colin DJ,Trajkovski M
22-7770 was used in Flow cytometry/Cell sorting to show that caloric restriction stimulates development of functional beige fat within the subcutaneous and visceral adipose tissue in mice.
Tue Sep 13 00:00:00 EDT 2016
Synergistically increased ILC2 and Th9 cells in lung tissue jointly promote the pathological process of asthma in mice.
Molecular medicine reports
Ying X,Su Z,Bie Q,Zhang P,Yang H,Wu Y,Xu Y,Wu J,Zhang M,Wang S,Xu H
22-7770 was used in Flow cytometry/Cell sorting to investigate the response state of lung tissue with regards to Th9 and innate lymphoid cells 2 in a mouse model of asthma.
Wed Jun 01 00:00:00 EDT 2016