•Purity: >95% by SDS-Page
•Endotoxin Concentration: ≤1 EUs/µg
•Protein Length: 175 aa.
•Biological Activity: <5 ng/mL
•Molecular Weight: 18.7 kDa
•Animal Origin Free: Yes
Thrombopoietin (TPO, THPO, MPL ligand, megakaryocyte colony-stimulating factor) is responsible for the generation of platelets through its action on hematopoietic cells committed to the megakaryocyte lineage. Binding of thrombopoietin to its receptor, MPL (CD110), initiates a signaling cascade via JAK/STAT, MAPK, and PI3K/AKT signaling pathways that leads to the proliferation and differentiation of megakaryocytes and, ultimately, to the production of platelets (thrombopoiesis). Thrombopoietin is constitutively produced by the liver and has a predicted molecular weight of 38 kDa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: C-mpl ligand; Megakaryocyte colony-stimulating factor; Megakaryocyte growth and development factor; MGDF; ML; Myeloproliferative leukemia virus oncogene ligand; Thrombopoietin
Gene Aliases: Mgdf; Ml; Mpllg; Thpo; Tpo
UniProt ID: (Mouse) P40226
Entrez Gene ID: (Mouse) 21832