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|Tested species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to the cytoplasmic tail of human MUC1.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.4, with 1% BSA|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100|
|Immunoprecipitation (IP)||Assay dependent|
|Western Blot (WB)||Assay dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-21077 detects MUC1 in human and mouse samples.
PA1-21077 has been successfully used in immunohistochemistry (paraffin), immunoprecipitation, immunofluorescence, and Western blot procedures. Positive controls of MCF-7 cells and Breast carcinoma suggested.
The PA1-21077 immunogen is a synthetic peptide corresponding to the cytoplasmic tail of human MUC1.
MUC-1 is a heavily O-glycosylated transmembrane protein expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and overexpressed abundantly in >90% breast carcinomas and metastases. Transgenic MUC-1 has been shown to associate with all four cebB receptors and localize with erbB1 (EGFR) in lactating glands.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
breast carcinoma-associated antigen DF3; cancer antigen 15-3; carcinoma-associated mucin; CD227; DF3 antigen; EMA; episialin; Epithelial Membrane Antigen; H23 antigen; KL-6; krebs von den Lungen-6; MAM6; Medullary cystic kidney disease, autosomal dominant; MUC-1/SEC; MUC-1/X; MUC1/ZD; mucin 1, transmembrane; mucin-1; peanut-reactive urinary mucin; PEM; polymorphic epithelial mucin; PUM; tumor associated epithelial mucin; tumor-associated epithelial membrane antigen
ADMCKD; ADMCKD1; CA 15-3; CD227; EMA; H23AG; KL-6; MAM6; MCD; MCKD; MCKD1; MUC-1; MUC-1/SEC; MUC-1/X; MUC1; MUC1/ZD; PEM; PEMT; PUM