|Immunohistochemistry (Paraffin) (IHC (P))||1:150|
|Immunohistochemistry (IHC)||See 2 publications below|
|Tested Species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Human breast cell line ZR-75-1|
|Storage buffer||PBS, pH 7.6, with 0.2% BSA|
|Contains||15mM sodium azide|
|Storage conditions||4° C|
MA5-11227 targets MUC-1 in IHC (P) applications and shows reactivity with Human samples.
The MA5-11227 immunogen is human breast cell line ZR-75-1.
MUC-1 is a heavily O-glycosylated transmembrane protein expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and overexpressed abundantly in >90% breast carcinomas and metastases. Transgenic MUC-1 has been shown to associate with all four cebB receptors and localize with erbB1 (EGFR) in lactating glands.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: breast carcinoma-associated antigen DF3; cancer antigen 15-3; carcinoma-associated mucin; CD227; DF3 antigen; EMA; episialin; Epithelial Membrane Antigen; H23 antigen; KL-6; krebs von den Lungen-6; MAM6; MUC-1; MUC-1/SEC; MUC-1/X; MUC1/ZD; mucin 1, transmembrane; mucin-1; peanut-reactive urinary mucin; PEM; polymorphic epithelial mucin; PUM; tumor associated epithelial mucin; tumor-associated epithelial membrane antigen; tumor-associated mucin
Gene Aliases: CA 15-3; CD227; EMA; H23AG; KL-6; MAM6; MCKD1; MUC-1; MUC-1/SEC; MUC-1/X; MUC1/ZD; PEM; PEMT; PUM; RP11-263K19.2
UniProt ID: (Human) P15941
Entrez Gene ID: (Human) 4582
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