|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Human breast cell line ZR-75-1|
|Storage buffer||PBS, pH 7.6, with 0.2% BSA|
|Contains||15mM sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:150|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (IHC)||See 2 publications below|
MA5-11227 targets MUC-1 in IHC (P) applications and shows reactivity with Human samples.
The MA5-11227 immunogen is human breast cell line ZR-75-1.
MUC-1 is a heavily O-glycosylated transmembrane protein expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and overexpressed abundantly in >90% breast carcinomas and metastases. Transgenic MUC-1 has been shown to associate with all four cebB receptors and localize with erbB1 (EGFR) in lactating glands.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
MUC5AC, cytokeratin 20 and HER2 expression and K-RAS mutations within mucinogenic growth in congenital pulmonary airway malformations.
MA5-11227 was used in immunohistochemistry to investigate the changes of gene expression in congenital pulmonary airway malformations
|Rossi G,Gasser B,Sartori G,Migaldi M,Costantini M,Mengoli MC,Piccioli S,Cavazza A,Rivasi F||Histopathology (60:1133)||2012|
Exploring the peritoneal surface malignancy phenotype--a pilot immunohistochemical study of human pseudomyxoma peritonei and derived animal models.
MA5-11227 was used in immunohistochemistry to characterize the expression of a number of proteins in tissues from pseudomyxoma peritonei patients
|Flatmark K,Davidson B,Kristian A,Stavnes HT,Førsund M,Reed W||Human pathology (41:1109)||2010|