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|Tested species reactivity||Mouse|
|Host / Isotype||Rabbit|
|Immunogen||A synthetic peptide from aa 150-210 of mouse Mucolipin 1 conjugated to an immunogenic carrier protein|
|Storage buffer||whole serum|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:300-1:2000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Glycerol (1:1) may be added for additional stability.
Reconstitute in 100 µL of sterile water.
Polycystin cation channel contains the cation channel region of PKD1 and PKD2 proteins; pfam08016. Cationic channel probably playing a role in the endocytic pathway and in the control of membrane trafficking of proteins and lipids. Could play a major role in Ca(2+) transport regulating lysosomal exocytosis. Forms multimeric complexes. Widely expressed, with the highest expression in brain, liver and kidney. MISCELLANEOUS: Channel function is transiently modulated by changes in Ca(2+), and inhibited by a reduction of pH; pH changes modify the aggregation state of unitary channels.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
2210015I05Rik; MCLN1; Mcoln1; MGC7172; Mucolipin 1; mucolipin-1; TRPML1
2210015I05Rik; Mcoln1; mucolipidin; TRPML1