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|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||Human Mus81 from Sp2/0 Ag.14 cells|
|Contains||0.1% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:10000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 1 publications below|
MA1-5837 detects Mus81 in human samples.
MA1-5837 has been successfully used in Western blot and immunoprecipitation procedures.
The MA1-5837 immunogen is human Mus81.
Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
UHRF1 contributes to DNA damage repair as a lesion recognition factor and nuclease scaffold.
MA1-5837 was used in western blot to study the role of UHRF1 to DNA lesions.
|Tian Y,Paramasivam M,Ghosal G,Chen D,Shen X,Huang Y,Akhter S,Legerski R,Chen J,Seidman MM,Qin J,Li L||Cell reports (10:1957)||2015|
FLJ21012; FLJ44872 MUS81; MUS81 endonuclease homolog; SLX3 structure-specific endonuclease subunit homolog