|Immunohistochemistry (Paraffin) (IHC (P))||5-10 µg/ml|
|Western Blot (WB)||0.2-1 µg/ml|
|Tested Species reactivity||Dog, Human, Non-human primate, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to residues 250-300 of human MYADM.|
|Purification||Antigen affinity chromatography|
|Contains||0.05% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
This antibody is predicted to react with human, bovine, mouse and chimpanzee based on sequence homology.
MYADM, belonging to the MAL family, is a 322-amino acid protein having 7 hydrophobic transmembrane domains, several potential consensus sites for phosphorylation and sequence homology with the T-cell differentiation protein MAL and plasmolipin. It shares 75.8% sequence identity with mouse in the transmembrane regions and is associated with differentiation of hematopoietic cells or acute promyelocytic leukemia cells. Its expression is up-regulated in NB4 cells induced by all-trans retinoic acid whereas down regulation inhibits colony formation of bone marrow cells. MYADM could serve as a new marker for hematopoietic differentiation and is a target for diagnostic, prognostic and/or therapeutic interventions. It is known to express widely in brain and pancreatic islet cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: MYADM; Myeloid up-regulated protein; myeloid upregulated protein; Myeloid-associated differentiation marker; Protein SB135
Gene Aliases: MYADM; SB135; UNQ553/PRO1110
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