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|Tested species reactivity||Human|
|Published species reactivity||Rat, Human, Mouse|
|Host / Isotype||Mouse / IgG2b|
|Immunogen||Purified, full length, native, human myeloperoxidase protein.|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay dependent|
|Western Blot (WB)||Assay dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (IHC)||See 11 publications below|
MA1-20074 detects Myeloperoxidase in human samples.
MA1-20074 has been successfully used in ELISA and Western blot procedures.
The MA1-20074 immunogen is purified, full length, native, human myeloperoxidase protein.
Part of the host defense system of polymorphonuclear leukocytes, Myeloperoxidase is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
In situ analysis of interleukin-23- and interleukin-12-positive cells in the spine of patients with ankylosing spondylitis.
MA1-20074 was used in immunohistochemistry to study the presence and source of IL-12 and IL-23 in patients with ankylosing spondylitis
|Appel H,Maier R,Bleil J,Hempfing A,Loddenkemper C,Schlichting U,Syrbe U,Sieper J||Arthritis and rheumatism (65:1522)||2013|
Ligation of the jugular veins does not result in brain inflammation or demyelination in mice.
MA1-20074 was used in immunohistochemistry to study whether chronic cerebrospinal venous insufficiency is a cause of multiple sclerosis using a murine model
|Atkinson W,Forghani R,Wojtkiewicz GR,Pulli B,Iwamoto Y,Ueno T,Waterman P,Truelove J,Oklu R,Chen JW||PloS one (7:null)||2012|
Omega 3 fatty acids supplementation has an ameliorative effect in experimental ulcerative colitis despite increased colonic neutrophil infiltration.
MA1-20074 was used in immunohistochemistry to study the efficacy of omega 3 fatty acids in the treatment of experimental ulcerative colitis
|Varnalidis I,Ioannidis O,Karamanavi E,Ampas Z,Poutahidis T,Taitzoglou I,Paraskevas G,Botsios D||Revista espan¿ola de enfermedades digestivas : organo oficial de la Sociedad Espan¿ola de Patologi¿a Digestiva (103:511)||2011|
Tempol, a membrane-permeable radical scavenger, ameliorates lipopolysaccharide-induced acute lung injury in mice: a key role for superoxide anion.
MA1-20074 was used in immunohistochemistry to study the mechanism by which a membrane-permeable radical scavenger protects against lipopolysaccharide-induced acute lung injury
|El-Sayed NS,Mahran LG,Khattab MM||European journal of pharmacology (663:68)||2011|
Distinguishing inflammation from tumor and peritumoral edema by myeloperoxidase magnetic resonance imaging.
MA1-20074 was used in immunohistochemistry to study the use of myeloperoxidase magnetic resonance imaging to differentiate inflammation from tumor/peritumor edema in gliomas
|Kleijn A,Chen JW,Buhrman JS,Wojtkiewicz GR,Iwamoto Y,Lamfers ML,Stemmer-Rachamimov AO,Rabkin SD,Weissleder R,Martuza RL,Fulci G||Clinical cancer research : an official journal of the American Association for Cancer Research (17:4484)||2011|
Protective role of simvastatin on lung damage caused by burn and cotton smoke inhalation in rats.
MA1-20074 was used in immunohistochemistry to study the effect of simvastatin lung injury caused by burn and smoke inhalation
|Belli S,Basaran O,Ozdemir BH,Türkoğlu S,Karabay G,Kut A,Karakayali H,Haberal M||The Journal of surgical research (167:e283)||2011|
Hyperglycaemia but not hyperlipidaemia decreases serum amylase and increases neutrophils in the exocrine pancreas of cats.
MA1-20074 was used in immunohistochemistry to study the effects of hyperglycaemia or hyperlipidaemia on the levels of serum amylase and neutrophils in the exocrine pancreas of cats
|Zini E,Osto M,Moretti S,Franchini M,Kook PH,Lutz H,Guscetti F,Perren A,Hoelzle LE,Ackermann M,Lutz TA,Reusch CE||Research in veterinary science (89:20)||2010|
Caveolin-1 expression determines the route of neutrophil extravasation through skin microvasculature.
MA1-20074 was used in immunohistochemistry to investigate the role of caveolin-1 in the guidence of neutrophil transmigration
|Marmon S,Hinchey J,Oh P,Cammer M,de Almeida CJ,Gunther L,Raine CS,Lisanti MP||The American journal of pathology (174:684)||2009|
Helicobacter pylori-secreted factors inhibit dendritic cell IL-12 secretion: a mechanism of ineffective host defense.
MA1-20074 was used in immunohistochemistry to study the role of Helicobacter pylori-secreted factors in the inhibition of dendritic cell IL-12 secretion
|Kao JY,Rathinavelu S,Eaton KA,Bai L,Zavros Y,Takami M,Pierzchala A,Merchant JL||American journal of physiology. Gastrointestinal and liver physiology (291:G73)||2006|
Mechanisms of c-reactive protein up-regulation in arterialized vein grafts.
MA1-20074 was used in immunohistochemistry to study the molecular basis of c-reactive protein up-regulation in arterialized vein grafts
|Gulkarov I,Pintucci G,Bohmann K,Saunders PC,Sullivan RF,Ferrari G,Mignatti P,Galloway AC||Surgery (139:254)||2006|
Biliary intervention augments chemotactic reaction and aggravates cholestatic liver injury in rats.
MA1-20074 was used in immunohistochemistry to study the mechanism by which biliary intervention stimulates chemotactic responses and worsens liver damage in a rat model of cholestatic liver injury
|Chuang JH,Chang NK,Huang CC,Lo SK,Wang HC,Chen CM,Wu CL,Chou MH,Lin TK||The Journal of surgical research (120:210)||2004|