Detects myozap (myocardium zonula adherens protein), a major 54 kD polypeptide present in myocardial junctions (composite junctions in the intercalated disks), also localized in adherens type junctions of the entire cardiovascular system and in endothelia of the blood and lymph vascular systems.Reactivity on cultured cell lines: HL-1, HUVEC.Positive control: myocard.
This gene (Gcom1) is part of a complex transcript unit that includes the gene for glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A (GRINL1A). Transcription of this gene occurs at an upstream promoter, with two different groups of alternatively spliced variants: Gup for GRINL1A upstream transcripts and Gcom for GRINL1A combined transcripts. The GRINL1A gene uses a downstream promoter for transcription and also has multiple alternatively spliced variants.
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Protein Aliases: DNA-directed RNA polymerase II subunit GRINL1A; DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5; DNA-directed RNA polymerase II subunit M; DNA-directed RNA polymerase II subunit M, isoforms 4/5; gcom; Gcom2; Gdown1; glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A; Glutamate receptor-like protein 1A; GRINL1A downstream protein 1; GRINL1A downstream protein Gdown4; GRINL1A upstream protein; Gup; Myocardial zonula adherens protein; MYZAP-POLR2M; polymerase (RNA) II (DNA directed) polypeptide M; polymerase (RNA) II subunit M; protein GRINL1A; protein GRINL1A, isoforms 4/5
Gene Aliases: AA407243; AA408799; AI303746; AW553238; D9Wsu138e; GCOM1; Gdown; Gdown1; Glurr; GRINL1A; mKIAA4185; MYOZAP; MYZAP; POLR2M