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MyoZap Monoclonal Antibody (517.67)
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Product Details
651169PROGEN
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Mouse,
Pig,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
517.67
Immunogen
Synthetic Peptide Of Human Myozap (Myocardium Zonula Adherens Protein)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
Conc. Not Determined
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Detects myozap (myocardium zonula adherens protein), a major 54 kD polypeptide present in myocardial junctions (composite junctions in the intercalated disks), also localized in adherens type junctions of the entire cardiovascular system and in endothelia of the blood and lymph vascular systems.Reactivity on cultured cell lines: HL-1, HUVEC.Positive control: myocard.
Target Information
MYOZAP, also known as GRINL1A, is a 54 kDa highly conserved cardiac protein. It is strongly expressed in the heart and lung and is a novel component of intercalated disc. MYOZAP interacts with myosin phosphatase-RhoA interacting protein (MRIP) and acts as an activator of Rho-dependent SRF signaling. Knockdown study in zebrafish results in cardiomyopathy with severe dysfunction. The MYOZAP gene is part of a complex transcript unit that includes the gene for glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A (GRINL1A). Transcription of this gene occurs at an upstream promoter, with two different groups of alternatively spliced variants: Gup for GRINL1A upstream transcripts and Gcom for GRINL1A combined transcripts.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: gcom; Gcom2; GRINL1A; GRINL1A combined protein; GRINL1A complex locus 1; GRINL1A complex locus protein 1; GRINL1A complex locus upstream; GRINL1A upstream protein; Gup2; myocardial intercalated disc protein; myocardium-enriched ZO1-associated protein; myocardium-enriched zonula adherens protein; myocardium-enriched zonula occludens-1-associated protein; myozap; MYZAP-POLR2M; putative NMDAR1 subunit-interacting protein; Gup1; unnamed protein product
Gene Aliases: CMD2K; GCOM1; Gm20502; Gm640; Grinl1a7; Gup; MYOZAP
UniProt ID: (Human) P0CAP1, (Mouse) Q3UIJ9, (Rat) Q5EB94
Entrez Gene ID: (Pig) 100154487, (Human) 100820829, (Mouse) 102371, (Rat) 363091
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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