|Tested species reactivity||Human|
|Published species reactivity||Not Applicable|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Purified recombinant fragment of Myostatin expressed in E. Coli.|
|Contains||0.03% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||1/500 - 1/2000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 1 publications below|
MA5-15486 targets Myostatin in WB applications and shows reactivity with Human samples.
The MA5-15486 immunogen is purified recombinant fragment of Myostatin expressed in E. Coli.
MA5-15486 detects Myostatin which has a predicted molecular weight of approximately 42.7kDa.
The protein encoded by this gene is a member of the bone morphogenetic protein family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. This gene is thought to encode a secreted protein which negatively regulates skeletal muscle growth.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Overexpression of Latent TGFß Binding Protein 4 in Muscle Ameliorates Muscular Dystrophy through Myostatin and TGFß.
MA5-15486 was used in western blot to study how overexpression of latent TGFbeta binding protein 4 in muscle ameliorates muscular dystrophy through TGFbeta and myostatin
|Lamar KM,Bogdanovich S,Gardner BB,Gao QQ,Miller T,Earley JU,Hadhazy M,Vo AH,Wren L,Molkentin JD,McNally EM||PLoS genetics (12:null)||2016|