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|Tested species reactivity||Not Applicable|
|Host / Isotype||E.coli|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Control (Ctrl)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Recombinant human Myostatin is a non-glycosylated homodimer, containing two 109 amino acid chains, with a total molecular weight of 24.8 kDa. Purity is typically greater than 95% and endotoxin level less than 1 EU/ug.
The expected biological activity (ED50) is determined by the inhibition of the proliferation of MPC-11 cells and is typically less than 20 ng/mL. The specific activity of this protein is 5x10^5 units/mg.
Reconstitute using sterile 20mM HCl at 0.1 mg/ml and centrifuge prior to opening vial. Gently pipet solution down the sides of the vial. DO NOT VORTEX sample. Store reconstituted material at -20°C and add 0.1% BSA for additional stability.
Amino acid sequence: DFGLDCDEHS TESRCCRYPL TVDFEAFGWD WIIAPKRYKA NYCSGECEFV FLQKYPHTHL VHQANPRGSA GPCCTPTKMS PINMLYFNGK EQIIYGKIPA MVVDRCGCS.
Myostatin is a member of the TGF-beta superfamily that is essential for proper regulation of skeletal muscle mass in a number of species ranging from fish to humans. Myostatin is a secreted protein that negatively regulates skeletal muscle mass determining both muscle fiber number and size. Inhibition of myostatin can increase muscle mass in a number of animal models of human disease, including muscular dystrophy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
GDF-8; Growth/differentiation factor 8; H-Myostatin; Myostatin
GDF8; MSLHP; MSTN