This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: NGDLDEVKDY VAKGEDVNRT LEGGRKPLHY AADCGQLEIL EFLLLKGADI NAPDKHHITP LLSAVYEGHV SCVKLLLSKG ADKTVKGPDG LTAFEATDNQ AIKALLQ
Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 99%.
The transcript produced from this gene is bi-cistronic and can encode both myotrophin and leucine zipper protein 6. The myotrophin protein is associated with cardiac hypertrophy, where it is involved in the conversion of NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers. This protein also has a potential function in cerebellar morphogenesis, and it may be involved in the differentiation of cerebellar neurons, particularly of granule cells. A cryptic ORF at the 3' end of this transcript uses a novel internal ribosome entry site and a non-AUG translation initiation codon to produce leucine zipper protein 6, a 6. 4 kDa tumor antigen that is associated with myeloproliferative disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Granule cell differentiation protein; growth factor; Myotrophin; Protein V-1; stimulates myocyte growth; V-1 protein
Gene Aliases: 5033418D15Rik; GCDP; MTPN; V-1; V1