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NeoBiotechnologies
N-Cadherin/Cadherin-2/CD325 (NCAD) Monoclonal Antibody (MNCD2)
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Product Details
1000-RTM6-P0
Applications
Tested Dilution
Publications
Product Specifications
Host/Isotype
Rat
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
MNCD2
Immunogen
Recombinant fragment (aa308-597) around mouse CDH2. The epitope is the extracellular domain of N-cadherin.
Conjugate
Form
Liquid
Concentration
200 µg/mL
Storage conditions
4°C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
N-cadherin is a 140 kDa protein belonging to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion through homotypic adhesion with the same cadherin species. N-cadherin's function is dependent on its association with the actin-cytoskeleton and is mediated through interactions between the C-terminal region of N-cadherin and the cytoplasmic catenin proteins. The stability of this association is regulated by phosphorylation and dephosphorylation of beta-catenin. Further, N-cadherin is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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