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N-cadherin Polyclonal Antibody

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12 Published Figures

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Questions & Answers

Questions & Answers

N-cadherin Antibody in Immunocytochemistry (ICC/IF)

N-cadherin Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 24

N-cadherin Antibody (PA5-29570) in ICC/IF

Immunocytochemistry-Immunofluorescence analysis of N-cadherin was performed in NT2D1 cells fixed in 4% paraformaldehyde at RT for 15 min. Green: N-cadherin Polyclonal Antibody (Product # PA5-29570) diluted at 1:500. Blue: Hoechst 33342 staining.

N-cadherin Antibody in Immunocytochemistry (ICC/IF)

N-cadherin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

N-cadherin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

N-cadherin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

N-cadherin Antibody in Western Blot (WB)

N-cadherin Antibody in Western Blot (WB)

N-cadherin Antibody in Western Blot (WB)

N-cadherin Antibody in Western Blot (WB)

N-cadherin Antibody in Western Blot (WB)

N-cadherin Antibody in Western Blot (WB)

N-cadherin Antibody in Western Blot (WB)

N-cadherin Antibody in Western Blot (WB)

N-cadherin Antibody in Western Blot (WB)

N-cadherin Antibody in Western Blot (WB)

N-cadherin Antibody in Immunohistochemistry (IHC)

N-cadherin Antibody in Immunohistochemistry (IHC)

N-cadherin Antibody in Western Blot, Immunohistochemistry (WB, IHC)

N-cadherin Antibody in Western Blot (WB)

N-cadherin Antibody in Western Blot (WB)

N-cadherin Antibody in Western Blot (WB)

N-cadherin Antibody in Western Blot (WB)

N-cadherin Antibody in Western Blot (WB)

N-cadherin Antibody in Western Blot (WB)

N-cadherin Antibody

Product Image Gallery

N-cadherin Antibody in Immunocytochemistry (ICC/IF) — Immunocytochemistry-Immunofluorescence analysis of N-cadherin was performed in NT2D1 cells fixed in 4% paraformaldehyde at RT for 15 min. Green: N-cadherin Polyclonal Antibody (Product # PA5-29570) diluted at 1:500. Blue: Hoechst 33342 staining.

N-cadherin Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry (Paraffin) analysis of N-cadherin was performed in paraffin-embedded mouse liver tissue using N-cadherin Polyclonal Antibody (Product # PA5-29570) at a dilution of 1:500. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min.

N-cadherin Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry (Paraffin) analysis of N-cadherin was performed in paraffin-embedded rat liver tissue using N-cadherin Polyclonal Antibody (Product # PA5-29570) at a dilution of 1:500. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min.

N-cadherin Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — N-cadherin Polyclonal Antibody detects CDH2 protein at membrane on hepatoma by immunohistochemical analysis. Sample: Paraffin-embedded human hepatoma. N-cadherin Polyclonal Antibody (Product # PA5-29570) dilution: 1:500. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.

N-cadherin Antibody in Western Blot (WB) — N-cadherin Polyclonal Antibody detects N-Cadherin protein by western blot analysis. A. 30 µg PC-12 whole cell extract. B. 30 µg Rat2 whole cell extract.5% SDS-PAGE. N-cadherin Polyclonal Antibody (Product # PA5-29570) dilution: 1:1,000. The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.

N-cadherin Antibody in Western Blot (WB) — Western Blot analysis of N-cadherin was performed by separating 50 µg of Mouse tissue extracts by 7.5% SDS-PAGE. Proteins were transferred to a membrane and probed with a N-cadherin Polyclonal Antibody (Product # PA5-29570) at a dilution of 1:500. The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.

N-cadherin Antibody in Western Blot (WB) — Western Blot using N-cadherin Polyclonal Antibody (Product # PA5-29570). Various whole cell extracts (30 µg) were separated by 5% SDS-PAGE, and the membrane was blotted with N-cadherin Polyclonal Antibody (Product # PA5-29570) diluted at 1:1,000. The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.

N-cadherin Antibody in Western Blot (WB) — Western Blot analysis of N-cadherin was performed by separating 30 µg of Whole cell extracts by 7.5% SDS-PAGE. Proteins were transferred to a membrane and probed with a N-cadherin Polyclonal Antibody (Product # PA5-29570) at a dilution of 1:1000. The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.

N-cadherin Antibody in Western Blot (WB) — Western Blot analysis of N-cadherin was performed by separating 50 µg of Rat tissue extracts by 7.5% SDS-PAGE. Proteins were transferred to a membrane and probed with a N-cadherin Polyclonal Antibody (Product # PA5-29570) at a dilution of 1:1000. The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.

N-cadherin Antibody in Western Blot (WB) — Western Blot using N-cadherin Polyclonal Antibody (Product # PA5-29570). Various tissue extracts (50 µg) were separated by 5% SDS-PAGE, and the membrane was blotted with N-cadherin Polyclonal Antibody (Product # PA5-29570) diluted at 1:1,000. The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.

N-cadherin Antibody in Western Blot (WB) — Western Blot analysis of N-cadherin was performed by separating 30 µg of various whole cell extracts by 7.5% SDS-PAGE. Proteins were transferred to a membrane and probed with a N-cadherin Polyclonal Antibody (Product # PA5-29570) at a dilution of 1:1000 and a HRP-conjugated anti-rabbit IgG secondary antibody.

N-cadherin Antibody in Western Blot (WB) — 7 FIGURE MiR-7-5p targeted PFN2 to repress the malignancy of NSCLC cells. (a and b) WB and RT-qPCR validated the knockdown efficiencies of si-PFN2 and in-miR-7-5p in NCI-H460 cells and the overexpression efficiencies of PFN2 and miR-7-5p in A549 cells. (c-n) The proliferation, apoptosis, metastasis, and invasion of NCI-H460 cells transfected with in-miR-NC, in-miR-7-5p, in-miR-7-5p + si-con, or in-miR-7-5p + si-PFN2 and A549 cells transfected with miR-NC, miR-7-5p, miR-7-5p + pcDNA, or miR-7-5p + PFN2 were determined by CCK-8, colony formation, EdU, flow cytometry, and transwell assays. (o and p) Protein levels of E-cadherin, N-cadherin, vimentin in NCI-H460 cells transfected with in-miR-NC, in-miR-7-5p, in-miR-7-5p + si-con, or in-miR-7-5p + si-PFN2 and A549 cells transfected with miR-NC, miR-7-5p, miR-7-5p + pcDNA, or miR-7-5p + PFN2 were analyzed by WB. * p < 0.05, ** p < 0.01, and *** p < 0.001

N-cadherin Antibody in Western Blot (WB) — 5 FIGURE CircATXN7 sponged miR-7-5p to regulate NSCLC cell malignancy. (a and b) RT-qPCR verified the overexpression efficiency of miR-7-5p in NCI-H460 cells and the knockdown efficiency of in-miR-7-5p in A549 cells. (c-n) The proliferation, apoptosis, metastasis, and invasion of NCI-H460 cells transfected with vector, circATXN7, circATXN7 + miR-NC, or circATXN7 + miR-7-5p and A549 cells transfected with sh-NC, sh-circATXN7, sh-circATXN7 + in-miR-NC, or sh-circATXN7 + in-miR-7-5p were analyzed by CCK-8, colony formation, EdU, flow cytometry, and transwell assays. (o, p) Protein levels of E-cadherin, N-cadherin, and Vimentin in NCI-H460 cells transfected with vector, circATXN7, circATXN7 + miR-NC, or circATXN7 + miR-7-5p and A549 cells transfected with sh-NC, sh-circATXN7, sh-circATXN7 + in-miR-NC, or sh-circATXN7 + in-miR-7-5p were detected by WB. * p < 0.05, ** p < 0.01, and *** p < 0.001

N-cadherin Antibody in Western Blot (WB) — Figure 6 ( A , B ) Cell EMT-related protein levels of E-cadherin, N-cadherin, Vimentin and beta-actin in AGS and ( C , D ) HGC-27 cells were investigated by Western blot. * p < 0.05, ** p < 0.01 and *** p < 0.001.

N-cadherin Antibody in Immunohistochemistry (IHC) — 8 FIGURE CircPRDM5 inhibited tumor tumorigenesis in vivo. (A) The effects of circPRDM5 overexpression on tumor volume. (B) The weight of tumors from the circPRDM5 group and vector group was measured. (C,D) quantitative real-time PCR and Western blotting assays were performed to detect the expression of circPRDM5, miR-485-3p and GCNT4 in the primary tumors from the circPRDM5 group and vector group. (E) immunohistochemistry assay was conducted to analyze the protein expression of ki67, E-cadherin, N-cadherin, and hexokinase 2 (HK2) in the primary tumors from the circPRDM5 group and vector group. * p < 0.05.

N-cadherin Antibody in Immunohistochemistry (IHC) — Fig. 5 UVRAG FS predisposes mice to colitis-associated colon cancer. a Representative macroscopic images of the colon from AOM-DSS-treated control (Ctrl) and iUVRAG FS mice in the presence/absence of Dox at the time of necropsy (day 60). Red arrows highlight colonic tumors. b - d The number ( b ), size ( c ), and overall load ( d ) of colonic tumors in AOM-DSS-treated mice in a . Tumor load is evaluated by totaling the diameters of all tumors in AOM-DSS-treated mice in a . n = 5-12 mice per genotype. e IHC staining of Ki67, cleaved caspase 3, p62, keratin 20, E-cadherin, N-cadherin, and vimentin in the colons from AOM-DSS-treated mice of indicated genotypes. Data are from one animal that is representative of 5-12 animals in each group. The levels of Ki67 staining (top right) and tumor apoptosis (bottom right) in the indicated colon were quantified. Arrows (red) denote cells undergoing apoptosis. Scale bars, 100 mum. f H&E-stained sections of the colon from AOM-DSS-treated mice in a . Data are from one animal that is representative of 5-12 animals in each group. Scale bars, 100 mum. g Histological scores for crypt damage (top) and total histological score (bottom) of colons from mice in a were quantified at day 60 as described in the Methods. n = 10 mice per group. h WB analysis of caspase-1 cleavage, IL-1beta production, LC3-I/II, and p62 levels in colon tissues of Dox-treated control and iUVRAG FS mice after AOM-DSS treatment. Data in h are from one experiment that is repres

N-cadherin Antibody in Western Blot, Immunohistochemistry (WB, IHC) — Figure 5 UVRAG FS activates Rac-1 and promotes tumour metastasis in vitro and vivo . ( a ) Rac-1 activation by UVRAG FS . Western blot shows a pull-down experiment to detect GTP-bound Rac1 in SW480.UVRAG FS cells and on drug treatment. Histogram shows quantification from three independent experiments. ( b ) Representative images of scratch-wound healing exhibit the motility of SW480.UVRAG FS cells. Cell motility into the wound area was taken at 0 and 16 h as marked by red lines. Wound-healing index was quantified (right). Data are the means+-s.d. ( n =3). ** P <0.01; *** P <0.001; NS, not significant. Histogram shows quantification from three independent experiments. ( c , d ) UVRAG FS enhances tumour metastasis in mice inoculated by intrasplenic injection of SW480.Vector and SW480.UVRAG FS cells. Schematic depiction of the procedure ( c , left) and representative images ( c , right) of upper abdominal organs at 8-week post-injection are shown ( c ). The number of metastatic nodules (liver and lung) was quantified ( d ). H&E staining was performed on serial sections of metastatic tumours (M) and normal (N) liver and lung are shown below. Scale bar, 1 mm. Arrows in c represent the metastasis foci. Results are representative of 10 mice per group. Fisher's exact test was used. ( e ) Immunohistochemistry analysis of autophagy, apoptosis and EMT status of primary tumours (left panel) and metastasis nodules (right panel). The bar graphs represent the quantification of the indi

N-cadherin Antibody in Western Blot (WB) — 6 FIGURE The impacts of the miR-485-3p/GCNT4 pathway on gastric cancer (GC) cell phenotypes. (A) Western blotting analysis was used to detect GCNT4 expression in MKN45 and HGC27 cells transfected with pcDNA3.1 or p-GCNT4. (B-J) MKN45 and HGC27 cells were divided into miR-NC, miR-485-3p, miR-485-3p + pcDNA3.1, and miR-485-3p + p-GCNT4 groups. (B) GCNT4 protein expression was analyzed by Western blotting. (C,D) Cell proliferation was assessed by cell colony formation assay and 5-ethynyl-2'-deoxyuridine (EdU) assay. (E,F) Cell migration and invasion were investigated by transwell assay. (G,H) ECAR was investigated by Seahorse XF Glycolysis Stress Test Kit. (I,J) The protein levels of ki67, E-cadherin, N-cadherin, and hexokinase 2 (HK2) were detected by Western blotting assay. * p < 0.05. ECAR, extracellular acidification rate.

N-cadherin Antibody in Western Blot (WB) — 4 FIGURE The effects of circPRDM5 and miR-485-3p on MKN45 and HGC27 cell phenotypes. (A) The efficiency of miR-485-3p overexpression was analyzed by quantitative real-time PCR ( qRT-PCR) in MKN45 and HGC27 cells. (B-I) MKN45 and HGC27 cells were transfected with vector, circPRDM5, circPRDM5 + miR-NC, or circPRDM5 + miR-485-3p. (B,C) Cell proliferation was investigated by cell colony formation and 5-ethynyl-2'-deoxyuridine (EdU) assays. (D,E) Cell migration and invasion were assessed by transwell assay. (F,G) Extracellular acidification rate (ECAR) was analyzed by Seahorse XF Glycolysis Stress Test Kit. (H,I) The protein expression of ki67, E-cadherin, N-cadherin, and hexokinase 2 (HK2) was detected by Western blotting analysis. * p < 0.05.

N-cadherin Antibody in Western Blot (WB) — 2 FIGURE CircPRDM5 inhibited gastric cancer (GC) progression. (A-I) MKN45 and HGC27 cells were transfected with vector, circPRDM5, sh-NC or sh-circPRDM5. (A) CircPRDM5 expression was analyzed by qRT-PCR. (B,C) Cell proliferation was assessed by cell colony formation and 5-ethynyl-2'-deoxyuridine (EdU) assays. (D,E) Cell migration and invasion were investigated by transwell assay. (F,G) ECAR was analyzed by Seahorse XF Glycolysis Stress Test Kit. (H,I) The protein expression of ki67, E-cadherin, N-cadherin, and hexokinase 2 (HK2) was detected by Western blotting analysis. * p < 0.05.

N-cadherin Antibody in Western Blot (WB) — 6 Figure MiR-944 combined with transmembrane O-mannosyltransferase targeting cadherins 3 (TMTC3) to repress hepatocellular carcinoma (HCC) cell malignancy. (A, B) The efficiency of miR-944 and TMTC3 overexpression was analyzed by quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot analysis, respectively, in Huh-7 and SNU-387 cells. (C-K) Huh-7 and SNU-387 cells were transfected with NC, miR-944, miR-944+ vector or miR-944 + TMTC3, and TMTC3 expression was analyzed by Western blot analysis (C), cell proliferation by cell counting kit-8 (CCK-8) assay, colony formation assay and EdU assay (D-F), cell migration and invasion by transwell assay and wound-healing assay (G-I), and the protein expression of PCNA, MMP2, MMP9, E-cadherin, N-cadherin, and Vimentin by Western blot analysis (J, K). (L) The effects of miR-944 and TMTC3 overexpression on the angiogenic capacity of HUVECs were analyzed by tube formation assay. * p < 0.05.

N-cadherin Antibody in Western Blot (WB) — 2 Figure CircMETTL15 knockdown inhibited hepatocellular carcinoma (HCC) cell proliferation, migration, invasion, and tube formation. (A) The efficiency of circMETTL15 knockdown was analyzed by quantitative real-time polymerase chain reaction (qRT-PCR) in Huh-7 and SNU-387 cells. (B-H) Huh-7 and SNU-387 cells were transfected with sh-NC or sh-circMETTL15#1, and cell proliferation was analyzed by cell counting kit-8 (CCK-8) assay, colony formation assay, and EdU assay (B-D), cell migration and invasion by transwell assay and wound-healing assay (E-G), and the protein expression of PCNA, MMP2, MMP9, E-cadherin, N-cadherin, and Vimentin by Western blot analysis (H). (I) The effect of circMETTL15 knockdown on the angiogenic capacity of HUVECs was analyzed by tube formation assay. * p < 0.05.

N-cadherin Antibody in Western Blot (WB) — The effects of PA on the expression of EMT and MMPs. ( A , C - E ) The Western blot band and quantification relative statistics of EMT-related proteins in the AGS cells. ( B , F - H ) The Western blot band and quantification relative statistics of the metastasis-associated proteins in AGS cells. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.

N-cadherin Antibody — Figure 5 UVRAG FS activates Rac-1 and promotes tumour metastasis in vitro and vivo . ( a ) Rac-1 activation by UVRAG FS . Western blot shows a pull-down experiment to detect GTP-bound Rac1 in SW480.UVRAG FS cells and on drug treatment. Histogram shows quantification from three independent experiments. ( b ) Representative images of scratch-wound healing exhibit the motility of SW480.UVRAG FS cells. Cell motility into the wound area was taken at 0 and 16 h as marked by red lines. Wound-healing index was quantified (right). Data are the means+-s.d. ( n =3). ** P <0.01; *** P <0.001; NS, not significant. Histogram shows quantification from three independent experiments. ( c , d ) UVRAG FS enhances tumour metastasis in mice inoculated by intrasplenic injection of SW480.Vector and SW480.UVRAG FS cells. Schematic depiction of the procedure ( c , left) and representative images ( c , right) of upper abdominal organs at 8-week post-injection are shown ( c ). The number of metastatic nodules (liver and lung) was quantified ( d ). H&E staining was performed on serial sections of metastatic tumours (M) and normal (N) liver and lung are shown below. Scale bar, 1 mm. Arrows in c represent the metastasis foci. Results are representative of 10 mice per group. Fisher's exact test was used. ( e ) Immunohistochemistry analysis of autophagy, apoptosis and EMT status of primary tumours (left panel) and metastasis nodules (right panel). The bar graphs represent the quantification of the indicated {TM}

Product Details

PA5-29570

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 6 publications 6 publications

Immunohistochemistry (IHC)

-

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000

-

Immunocytochemistry (ICC/IF)

1:100-1:1,000

-

Miscellaneous PubMed (Misc)

-

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fragment corresponding to a region within amino acids 79 and 387 of Human N-cadherin

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.19 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 1% BSA, 20% glycerol

Contains

0.025% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_2547046

Product Specific Information

Recommended positive controls: NT2D1, U87-MG, SK-N-SH, IMR-32, SK-N-AS, mouse brain, rat brain, PC-12, Rat2.

Predicted reactivity: Mouse (95%), Rat (95%), Xenopus laevis (85%), Dog (96%), Chicken (91%), Bovine (96%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

N-cadherin is a 140 kDa protein belonging to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion through homotypic adhesion with the same cadherin species. N-cadherin's function is dependent on its association with the actin-cytoskeleton and is mediated through interactions between the C-terminal region of N-cadherin and the cytoplasmic catenin proteins. The stability of this association is regulated by phosphorylation and dephosphorylation of beta-catenin. Further, N-cadherin is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

CircPRDM5 inhibits the proliferation, migration, invasion, and glucose metabolism of gastric cancer cells by reducing GCNT4 expression in a miR-485-3p-dependent manner.

The Kaohsiung journal of medical sciences

Lan ZZ,Sun FH,Chen C,Niu L,Shi JD,Zhang WY

Published figure using N-cadherin polyclonal antibody (Product # PA5-29570) in Western Blot

Fri Mar 01 00:00:00 UTC 2024

CircPRDM5 inhibits the proliferation, migration, invasion, and glucose metabolism of gastric cancer cells by reducing GCNT4 expression in a miR-485-3p-dependent manner.

The Kaohsiung journal of medical sciences

Lan ZZ,Sun FH,Chen C,Niu L,Shi JD,Zhang WY

Published figure using N-cadherin polyclonal antibody (Product # PA5-29570) in Western Blot

Fri Mar 01 00:00:00 UTC 2024

CircMETTL15 induces TMTC3 production by absorbing miR-944 to promote hepatocellular carcinoma cell malignancy.

Journal of biochemical and molecular toxicology

Zhao Y,Chen J,Xu S,Chen Y

Published figure using N-cadherin polyclonal antibody (Product # PA5-29570) in Western Blot

Mon Jan 01 00:00:00 UTC 2024

Betulonic Acid, as One of the Active Components of the Celastrus orbiculatus Extract, Inhibits the Invasion and Metastasis of Gastric Cancer Cells by Mediating Cytoskeleton Rearrangement In Vitro.

Molecules (Basel, Switzerland)

Chu Z,Luo Y,Ni T,Zhu M,Feng X,Liu Y,Wang H

Published figure using N-cadherin polyclonal antibody (Product # PA5-29570) in Western Blot

Wed Feb 02 00:00:00 UTC 2022

Betulonic Acid, as One of the Active Components of the Celastrus orbiculatus Extract, Inhibits the Invasion and Metastasis of Gastric Cancer Cells by Mediating Cytoskeleton Rearrangement In Vitro.

Molecules (Basel, Switzerland)

Chu Z,Luo Y,Ni T,Zhu M,Feng X,Liu Y,Wang H

Published figure using N-cadherin polyclonal antibody (Product # PA5-29570) in Western Blot

Wed Feb 02 00:00:00 UTC 2022

Poria Acid, Triterpenoids Extracted from Poria cocos, Inhibits the Invasion and Metastasis of Gastric Cancer Cells.

Molecules (Basel, Switzerland)

Wang H,Luo Y,Chu Z,Ni T,Ou S,Dai X,Zhang X,Liu Y

Published figure using N-cadherin polyclonal antibody (Product # PA5-29570) in Western Blot

Mon Jun 06 00:00:00 UTC 2022

Poria Acid, Triterpenoids Extracted from Poria cocos, Inhibits the Invasion and Metastasis of Gastric Cancer Cells.

Molecules (Basel, Switzerland)

Wang H,Luo Y,Chu Z,Ni T,Ou S,Dai X,Zhang X,Liu Y

Published figure using N-cadherin polyclonal antibody (Product # PA5-29570) in Western Blot

Mon Jun 06 00:00:00 UTC 2022

Downregulation of circATXN7 represses non-small cell lung cancer growth by releasing miR-7-5p.

Thoracic cancer

Li D,Fu Z,Dong C,Song Y

Published figure using N-cadherin polyclonal antibody (Product # PA5-29570) in Western Blot

Wed Jun 01 00:00:00 UTC 2022

Downregulation of circATXN7 represses non-small cell lung cancer growth by releasing miR-7-5p.

Thoracic cancer

Li D,Fu Z,Dong C,Song Y

Published figure using N-cadherin polyclonal antibody (Product # PA5-29570) in Western Blot

Wed Jun 01 00:00:00 UTC 2022

A minimal-complexity light-sheet microscope maps network activity in 3D neuronal systems.

Scientific reports

Wysmolek PM,Kiessler FD,Salbaum KA,Shelton ER,Sonntag SM,Serwane F

PA5-29570 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to create a 3D connectivity map of a stem cell derived neuron spheroid by imaging its activity.

Mon Nov 28 00:00:00 UTC 2022

A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice.

Nature communications

Quach C,Song Y,Guo H,Li S,Maazi H,Fung M,Sands N,O'Connell D,Restrepo-Vassalli S,Chai B,Nemecio D,Punj V,Akbari O,Idos GE,Mumenthaler SM,Wu N,Martin SE,Hagiya A,Hicks J,Cui H,Liang C

Published figure using N-cadherin polyclonal antibody (Product # PA5-29570) in Immunohistochemistry

Thu Dec 12 00:00:00 UTC 2019

Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancers.

Nature communications

He S,Zhao Z,Yang Y,O'Connell D,Zhang X,Oh S,Ma B,Lee JH,Zhang T,Varghese B,Yip J,Dolatshahi Pirooz S,Li M,Zhang Y,Li GM,Ellen Martin S,Machida K,Liang C

Published figure using N-cadherin polyclonal antibody (Product # PA5-29570) in Immunohistochemistry

Mon Aug 03 00:00:00 UTC 2015

Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancers.

Nature communications

He S,Zhao Z,Yang Y,O'Connell D,Zhang X,Oh S,Ma B,Lee JH,Zhang T,Varghese B,Yip J,Dolatshahi Pirooz S,Li M,Zhang Y,Li GM,Ellen Martin S,Machida K,Liang C

Published figure using N-cadherin polyclonal antibody (Product # PA5-29570) in Immunohistochemistry

Mon Aug 03 00:00:00 UTC 2015

Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancers.

Nature communications

He S,Zhao Z,Yang Y,O'Connell D,Zhang X,Oh S,Ma B,Lee JH,Zhang T,Varghese B,Yip J,Dolatshahi Pirooz S,Li M,Zhang Y,Li GM,Ellen Martin S,Machida K,Liang C

Published figure using N-cadherin polyclonal antibody (Product # PA5-29570) in Immunohistochemistry

Mon Aug 03 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: cadherin 2 type 1 N-cadherin (neuronal); cadherin 2, type 1, N-cadherin (neuronal); Cadherin-2; Cadherin-N; Cadherin2; calcium-dependent adhesion protein, neuronal; CD325; CDw325; CDw325 antigen; N-cadherin; N-cadherin 1; Neural cadherin

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Gene Aliases: CD325; CDH2; CDHN; CDw325; N-cadherin; NCAD

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UniProt ID: (Human) P19022, (Mouse) P15116, (Rat) Q9Z1Y3

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Entrez Gene ID: (Human) 1000, (Mouse) 12558, (Rat) 83501

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calcium ion binding protein binding beta-catenin binding protein kinase binding protein phosphatase binding protein complex binding alpha-catenin binding gamma-catenin binding nitric-oxide synthase binding enzyme binding metal ion binding cadherin

cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules glial cell differentiation calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules cell migration cerebral cortex development regulation of myelination adherens junction organization regulation of Rho protein signal transduction positive regulation of MAPK cascade cell-cell adhesion mediated by cadherin blood vessel morphogenesis brain morphogenesis homeostasis of number of cells regulation of axonogenesis striated muscle cell differentiation positive regulation of muscle cell differentiation protein heterooligomerization radial glial cell differentiation neuroepithelial cell differentiation regulation of oligodendrocyte progenitor proliferation establishment of protein localization to plasma membrane negative regulation of canonical Wnt signaling pathway neuroligin clustering involved in postsynaptic membrane assembly neuronal stem cell population maintenance regulation of postsynaptic density protein 95 clustering positive regulation of synaptic vesicle clustering synapse assembly regulation of signal transduction single organismal cell-cell adhesion regulation of protein localization

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