Immunogen sequence: IDFETNRMFV LTVAAENQVP LAKGIQHPPQ STATVSVTVI DVNENPYFAP NPKIIRQEEG LHAGTMLTTF TAQDPDRYMQ QNIRYTKLSD PANWLKIDPV N; Positive Samples: Mouse brain, Mouse heart, Rat heart; Cellular Location: Cell membrane, Single-pass type I membrane protein
N-cadherin is a 140 kDa protein belonging to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion through homotypic adhesion with the same cadherin species. N-cadherin's function is dependent on its association with the actin-cytoskeleton and is mediated through interactions between the C-terminal region of N-cadherin and the cytoplasmic catenin proteins. The stability of this association is regulated by phosphorylation and dephosphorylation of beta-catenin. Further, N-cadherin is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry.
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Protein Aliases: cadherin 2 type 1 N-cadherin (neuronal); cadherin 2, type 1, N-cadherin (neuronal); Cadherin-2; CD325; N-cadherin; Neural cadherin
Gene Aliases: Cdh2; CDHN; N-cadherin; Ncad
Molecular Function: cadherin