This Antibody was verified by Independent antibody to ensure that the antibody binds to the antigen stated. View Details
This antibody is specific for N-cadherin and does not cross-react with other cadherin family members including P- and E-cadherins.
For IHC with this antibody use formalin-fixed, paraffin-embedded tissue and heat-induced epitope retrieval.
N-cadherin is a 140 kDa protein belonging to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion through homotypic adhesion with the same cadherin species. N-cadherin's function is dependent on its association with the actin-cytoskeleton and is mediated through interactions between the C-terminal region of N-cadherin and the cytoplasmic catenin proteins. The stability of this association is regulated by phosphorylation and dephosphorylation of beta-catenin. Further, N-cadherin is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: cadherin 2 type 1 N-cadherin (neuronal); cadherin 2, type 1, N-cadherin (neuronal); Cadherin-2; Cadherin2; calcium-dependent adhesion protein, neuronal; CD325; CDw325; CDw325 antigen; N-cadherin; N-cadherin 1; Neural cadherin; neural calcium-dependent cell adhesion molecule; unnamed protein product
Gene Aliases: cadherin-2; CD325; CDH2; CDHN; CDw325; N-cadherin; NCAD
Molecular Function: cadherin