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|Tested species reactivity||Rat , Human , Mouse , Porcine , Chicken|
|Published species reactivity||Hamster , Human|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Recombinant domain corresponding to the intracellular domain of chicken N-Cadherin|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|Immunocytochemistry (ICC)||Assay Dependent|
|Immunofluorescence (IF)||Assay Dependent|
|Immunohistochemistry (IHC)||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
N-cadherin is a 140 kDa protein belonging to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion through homotypic adhesion with the same cadherin species. N-cadherin's function is dependent on its association with the actin-cytoskeleton and is mediated through interactions between the C-terminal region of N-cadherin and the cytoplasmic catenin proteins. The stability of this association is regulated by phosphorylation and dephosphorylation of beta-catenin.This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
14-3-3γ-Mediated transport of plakoglobin to the cell border is required for the initiation of desmosome assembly in vitro and in vivo.
33-3900 was used in immunohistochemistry to study the contribution of 4-3-3γ to testis organization and spermatogenesis.
|Sehgal L,Mukhopadhyay A,Rajan A,Khapare N,Sawant M,Vishal SS,Bhatt K,Ambatipudi S,Antao N,Alam H,Gurjar M,Basu S,Mathur R,Borde L,Hosing AS,Vaidya MM,Thorat R,Samaniego F,Kolthur-Seetharam U,Dalal SN||Journal of cell science (127:2174)||2014|
Molecular characterization of tumour heterogeneity and malignant mesothelioma cell differentiation by gene profiling.
33-3900 was used in immunohistochemistry and western blot to study the intrinsic molecular programs that determine tumor differentiation.
|Sun X,Wei L,Lidén J,Hui G,Dahlman-Wright K,Hjerpe A,Dobra K||The Journal of pathology (207:91)||2005|
A three-dimensional microenvironment alters protein expression and chemosensitivity of epithelial ovarian cancer cells in vitro.
33-3900 was used in western blot to compare the histological, biological, and molecular features of 2D and 3D epithelial ovarian cancer cultures.
|Lee JM,Mhawech-Fauceglia P,Lee N,Parsanian LC,Lin YG,Gayther SA,Lawrenson K||Laboratory investigation; a journal of technical methods and pathology (93:528)||2013|
The p63 protein isoform ΔNp63α inhibits epithelial-mesenchymal transition in human bladder cancer cells: role of MIR-205.
33-3900 was used in western blot to investigate the role of miR-205 in human bladder cancers.
|Tran MN,Choi W,Wszolek MF,Navai N,Lee IL,Nitti G,Wen S,Flores ER,Siefker-Radtke A,Czerniak B,Dinney C,Barton M,McConkey DJ||The Journal of biological chemistry (288:3275)||2013|
The canonical NF-kappaB pathway governs mammary tumorigenesis in transgenic mice and tumor stem cell expansion.
33-3900 was used in western blot to determine the role of mammary epithelial cell NF-kapaB signaling in tumor progression in vivo.
|Liu M,Sakamaki T,Casimiro MC,Willmarth NE,Quong AA,Ju X,Ojeifo J,Jiao X,Yeow WS,Katiyar S,Shirley LA,Joyce D,Lisanti MP,Albanese C,Pestell RG||Cancer research (70:10464)||2010|
Alpha5beta1 integrin mediates strong tissue cohesion.
||Robinson EE,Zazzali KM,Corbett SA,Foty RA||Journal of cell science (116:377)||2003|
The Erbin PDZ domain binds with high affinity and specificity to the carboxyl termini of delta-catenin and ARVCF.
||Laura RP,Witt AS,Held HA,Gerstner R,Deshayes K,Koehler MF,Kosik KS,Sidhu SS,Lasky LA||The Journal of biological chemistry (277:12906)||2002|
CD325, NCAD, CDHN, Ncad, CDw325, N-cadherin
N-cadherin, cadherin-2, neural cadherin, cadherin 2 type 1 N-cadherin (neuronal), cadherin 2, type 1, N-cadherin (neuronal), N-cadherin 1, cadherin 2, N-cadherin (neuronal), calcium-dependent adhesion protein, neuronal, neural-cadherin