|Tested species reactivity||Chicken, Human, Mouse, Non-human primate, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (39 CREKKTENSKLRKVKYE 55) of NAMPT/Visfatin protein.|
|Storage buffer||whole serum with 50% glycerol|
|Contains||0.025% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:1000-1:5000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
NAMPT is a 491 amino acid adipokine belonging to the NAPRTase family. It promotes angiogenesis via activation of the mitogen-activated protein kinase ERK-dependent pathway, is upregulated in neutrophils by IL-1beta, and functions as a novel inhibitor of apoptosis in response to a variety of inflammatory stimuli. It acts as a regulator of NAD+-dependent reactions in smooth muscle cells (SMCs) and in the pathogenesis of type 2 diabetes mellitus. NAMPT plays a role in insulin resistance and markers of hyperandrogenism in lean PCOS patients. It is a longevity protein that can add stress-resistant life to human smooth muscle cells by optimizing SIRT1-mediated p53 degradation. The expression level of NAMPT is high in visceral fat and serum levels in overweight and obese subjects with metabolic syndrome. It is expressed in large amounts in bone marrow, liver tissue, muscle, heart, placenta, lung and kidney tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.