This Antibody was verified by KnockDown to ensure that the antibody binds to the antigen stated. View Details
MA1-23265 detects NBS1 in Human samples.
MA1-23265 has been successfully used in Immunoprecipitation and Western Blot procedures. Predicted molecular weight 91 kDa. Positive control: MCF7, HeLa (NE), Raji.
MA1-23265 immunogen corresponds to The complete coding region of the human p95/NBS1 expressed in E. coli.
Store at 4°C short term. For extended storage aliquot and store at -20°C or below. Avoid freeze-thaw cycles.
Nijmegen breakage syndrome (NBS, nibrin) is an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The 1C3 antibody recognizes the 95 kDa NBS protein which contains a fork FHA head-associated domain that is adjacent to BRCT, a breast cancer C terminal domain, that has been implicated in protein-protein interactions. NBS is member of the Mre11/Rad50, p400 double-strand break repair complex involved in double-strand break repair and cell-cycle checkpoint functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: AT-V1; AT-V2; ATV; Cell cycle regulatory protein p95; FLJ10155; MGC87362; NBS; NBS1; Nibrin; Nijmegen breakage syndrome 1 (nibrin); Nijmegen breakage syndrome protein 1; Nijmegen breakage syndrome protein 1 homolog; P95; p95 protein of the MRE11/RAD50 complex
Gene Aliases: AT-V1; AT-V2; ATV; NBN; NBS; NBS1; P95