|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Homogenous suspension of 16 week human fetal brain.|
|Contains||0.02% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:10-1:500|
|Western Blot (WB)||1:100-1:2000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 2 publications below|
The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of a neuron-specific exon is thought to be functionally relevant.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Alterations in protein regulators of neurodevelopment in the cerebrospinal fluid of infants with posthemorrhagic hydrocephalus of prematurity.
MA1-46044 was used in western blot to study the changes in the cerebrospinal fluid of infants with post-hemorrhagic hydrocephalus
|Morales DM,Townsend RR,Malone JP,Ewersmann CA,Macy EM,Inder TE,Limbrick DD||Molecular and cellular proteomics : MCP (11:null)||2012|
Hepatocyte growth factor-induced ectodomain shedding of cell adhesion molecule L1: role of the L1 cytoplasmic domain.
MA1-46044 was used in western blot to study the role of the cytoplasmic domain of the cell adhesion molecule L1 in the HGF-induced shedding of its ectodomain
|Heiz M,Grünberg J,Schubiger PA,Novak-Hofer I||The Journal of biological chemistry (279:31149)||2004|