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|Tested species reactivity||Human, Rabbit|
|Host / Isotype||Mouse / IgG3|
|Immunogen||Fusion protein corresponding to full-length human NCF4 protein.|
|Storage buffer||PBS with 30% glycerol|
|Contains||0.02% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1-4 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-91529 detects NCF4 from rabbit, human samples.
MA1-91529 has been successfully used in Western blot applications.
The MA1-91529 immunogen is: Fusion protein corresponding to full-length human NCF4 protein.
The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
CTA-833B7.1; MGC3810; NCF; NCF-4; neutrophil cytosol factor 4; neutrophil NADPH oxidase factor 4; p40-phox; P40PHOX; SH3 and PX domain-containing protein 4; SH3PXD4
CTA-833B7.1; NCF; P40PHOX; SH3PXD4