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Invitrogen
NCK1 Recombinant Rabbit Monoclonal Antibody (K01_1U44)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA563395
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
K01_1U44
Immunogen
A synthetic peptide of human Nck.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
50mM tris glycine, pH 7.4, with 0.05% BSA, 40% glycerol, 150mM NaCl
Contains
0.01% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
NCK1 is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cytoplasmic protein NCK1; melanoma NCK protein; MGC12668; NCK adapter protein 1; NCK adaptor protein 1; NCK tyrosine kinase; non-catalytic region of tyrosine kinase; non-catalytic region of tyrosine kinase adaptor protein 1; SH2/SH3 adapter protein NCK-alpha; SH2/SH3 adaptor protein NCK-alpha; unnamed protein product
Gene Aliases: 6330586M15Rik; D230010O13Rik; NCK; Nck-1; NCKalpha
UniProt ID: (Human) P16333, (Mouse) Q99M51
Entrez Gene ID: (Human) 4690, (Rat) 300955, (Mouse) 17973
protein kinase inhibitor activity
receptor binding
protein binding
cytoskeletal adaptor activity
protein domain specific binding
receptor signaling complex scaffold activity
protein binding, bridging
receptor tyrosine kinase binding
signaling adaptor activity
cadherin binding
ephrin receptor binding
eukaryotic initiation factor eIF2 binding
protein sequestering activity
molecular condensate scaffold activity
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription from RNA polymerase II promoter
substrate-dependent cell migration, cell extension
actin filament organization
positive regulation of neuron projection development
cell migration
lamellipodium assembly
regulation of cell migration
positive regulation of actin filament polymerization
response to endoplasmic reticulum stress
regulation of translation initiation in response to endoplasmic reticulum stress
positive regulation of translation in response to endoplasmic reticulum stress
positive regulation of T cell proliferation
T cell activation
positive regulation of transcription from RNA polymerase II promoter
negative regulation of insulin receptor signaling pathway
ephrin receptor signaling pathway
negative regulation of T cell receptor signaling pathway
response to other organism
antiviral innate immune response
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
positive regulation of cap-dependent translational initiation
positive regulation of cap-independent translational initiation
negative regulation of PERK-mediated unfolded protein response
signal complex assembly
positive regulation of MAPK cascade
T cell receptor signaling pathway
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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