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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 182 and 448 of Human NCOA62|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 1% BSA, 20% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-29095 targets NCOA62 in IF, IHC (P), and WB applications and shows reactivity with Human samples.
The PA5-29095 immunogen is recombinant fragment corresponding to a region within amino acids 182 and 448 of Human NCOA62.
This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
62-kD; Bx42; homolog of Drosophila BX42; NCOA-62; nuclear protein SkiP; nuclear receptor coactivator; nuclear receptor coactivator NCoA-62; nuclear receptor coactivator, 62-kD; Prp45; PRPF45; SKI interacting protein; SKI-interacting protein; SKIIP; SKIP
Bx42; NCOA-62; Prp45; PRPF45; SKIIP; SKIP; SNW1