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Bioss

NCX1/SLC8A1 Polyclonal Antibody, Cyanine5.5

View all (21) SLC8A1 antibodies
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Datasheet
Protocols
Questions & Answers
Tech Support

Product Details

BS-1550R-CY55

Applications Tested Dilution Publications

Immunohistochemistry (Paraffin) (IHC (P))

 1:50-200 -

Immunohistochemistry (Frozen) (IHC (F))

 1:50-200 -

Immunocytochemistry (ICC/IF)

 1:50-200 -

Flow Cytometry (Flow)

 1:20-100 -
Product Specifications

Species Reactivity

 Human, Mouse, Rat

Host/Isotype

 Rabbit / IgG

Class

 Polyclonal

Type

 Antibody

Immunogen

KLH conjugated synthetic peptide derived from human NCX1
View immunogen

Conjugate

 Cyanine5.5

Excitation/Emission Max

 651/670 nm

Form

 Liquid

Concentration

 1 mg/mL

Purification

 Protein A

Storage buffer

 TBS with 50% glycerol, 1% BSA

Contains

 0.03% ProClin 300

Storage conditions

 -20°C or -80°C if preferred

Target Information

Ca2+ plays a critical role in intracellular signaling and thus regulation of calcium balance is critical for the maintenance of this signaling function. The plasma membrane Na+/Ca2+ (NaCX) exchangers mediate Na+-dependent Ca2+ efflux in a wide variety of cell types. NaCX can move Ca2+ either into or out of cells, depending on the net Na+, Ca2+, and K+ gradient across the membrane. In mammals, at least 5 distinct genes code for the exchangers: Three NaCX (NaCX-1, NaCX-2, and NaCX-3), and two in the NaCKX family (NaCKX-1 and NaCKX-2). NaCX-1 is most prominently expressed in the heart where it plays a major role in excitation-contraction coupling (Matsuoka et al., 1993). NACX-1 may also be a target for protection of the heart and brain from ischemia and reperfusion injury (Hagihara et al., 2005; Bano et al., 2005; Choi, 2005).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Na(+)/Ca(2+)-exchange protein 1; Na+/Ca++ exchanger; Na+/Ca2+ exchanger; Na-Ca exchanger; Na/Ca exchanger; Sodium/calcium exchanger 1; sodium/calcium exchanger isoform NaCa7; solute carrier family 8 (sodium/calcium exchanger), member 1; Solute carrier family 8 member 1; solute carrier family 8, member 1

Gene Aliases: AI852629; AV344025; CNC; D930008O12Rik; Ncx; NCX1; SLC8A1

UniProt ID: (Human) P32418, (Mouse) P70414, (Rat) Q01728

Entrez Gene ID: (Human) 6546, (Mouse) 20541, (Rat) 29715

Molecular Function: secondary carrier transporter

Function(s)
regulation of the force of heart contraction regulation of heart rate regulation of sodium ion transport ion transport cellular sodium ion homeostasis muscle contraction response to nutrient response to glucose regulation of cell communication by electrical coupling positive regulation of fibroblast migration regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion regulation of cardiac muscle contraction by calcium ion signaling vascular smooth muscle contraction telencephalon development positive regulation of bone mineralization response to ATP cellular response to reactive oxygen species sodium ion transmembrane transport response to immobilization stress response to muscle stretch response to drug response to hydrogen peroxide relaxation of smooth muscle negative regulation of cytosolic calcium ion concentration cardiac muscle cell development calcium ion homeostasis relaxation of cardiac muscle cardiac muscle contraction cytosolic calcium ion transport calcium ion transport into cytosol calcium ion import calcium ion transmembrane transport cellular response to caffeine cellular response to cAMP sodium ion export cellular response to hypoxia membrane depolarization during cardiac muscle cell action potential cell communication by electrical coupling involved in cardiac conduction sodium ion import positive regulation of the force of heart contraction calcium ion export regulation of cardiac conduction response to hypoxia embryonic placenta development heart morphogenesis transport sodium ion transport calcium ion transport cellular calcium ion homeostasis cell communication positive regulation of cytosolic calcium ion concentration post-embryonic development embryonic heart tube development muscle fiber development regulation of calcium ion transport transmembrane transport regulation of cardiac muscle cell membrane potential
Process(es)
calcium:sodium antiporter activity calcium ion binding protein binding calmodulin binding cytoskeletal protein binding ankyrin binding ion channel binding antiporter activity metal ion binding calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential
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