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|Tested species reactivity||Bovine, C. elegans, Fruit fly, Human, Mouse, Rat, Zebrafish|
|Published species reactivity||Mouse, Human|
|Host / Isotype||Mouse / IgG2a, kappa|
|Immunogen||Bovine Heart Complex I|
|Storage buffer||HEPES buffered saline|
|Contains||0.02% sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Western Blot (WB)||1.0 ug/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 3 publications below|
A novel gene associated with Retinoid-IFN-induced Mortality (GRIM) GRIM-19 gene was identified. Antisense expression of GRIM-19 confers a strong resistance against IFN/RA-induced death by reducing the intracellular levels of GRIM-19 protein. Overexpression of GRIM-19 enhances cell death in response to IFN/RA. GRIM-19 is primarily a nuclear protein whose expression is induced by the IFN/RA combination. These data indicate that GRIM-19 is a novel cell death-regulatory molecule.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Prevention and reversal of severe mitochondrial cardiomyopathy by gene therapy in a mouse model of Friedreich's ataxia.
43-9200 was used in western blot to assess the use of gene therapy in treating Friedreich's ataxia cardiomyopathy in a mouse model.
|Perdomini M,Belbellaa B,Monassier L,Reutenauer L,Messaddeq N,Cartier N,Crystal RG,Aubourg P,Puccio H||Nature medicine (20:542)||2014|
|Human||1:2000||The expression of nicotinamide N-methyltransferase increases ATP synthesis and protects SH-SY5Y neuroblastoma cells against the toxicity of Complex I inhibitors.||Parsons RB,Aravindan S,Kadampeswaran A,Evans EA,Sandhu KK,Levy ER,Thomas MG,Austen BM,Ramsden DB||The Biochemical journal (436:145)||2011|
|Human||Not Cited||Identification of alternatively spliced GRIM-19 mRNA in kidney cancer tissues.||He X,Cao X||Journal of human genetics (55:507)||2010|
B16.6; CDA016; Cell death regulatory protein GRIM-19; cell death-regulatory protein GRIM19; CGI-39; CI-B16.6; complex I B16.6 subunit; Complex I-B16.6; FLJ58045; FLJ59191; gene associated with retinoic and IFN-induced mortality 19 protein; Gene associated with retinoic and interferon-induced mortality 19 protein; Gene associated with retinoic-interferon-induced mortality 19 protein; genes associated with retinoid-IFN-induced mortality 19; GRIM-19; GRIM19; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13; NADH-ubiquinone oxidoreductase B16.6 subunit; YjeF N-terminal domain-containing protein 3; YjeF_N3
2700054G14Rik; AU022060; B16.6; BOS_7096; CDA016; CGI-39; GRIM-19; GRIM19; NDUFA13; Yjefn3