|Tested species reactivity||Bovine, C. elegans, Fruit fly, Human, Mouse, Rat, Zebrafish|
|Published species reactivity||Mouse, Human, Not Applicable|
|Host / Isotype||Mouse / IgG2a, kappa|
|Immunogen||Bovine Heart Complex I|
|Storage buffer||HEPES buffered saline|
|Contains||0.02% sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Western Blot (WB)||1.0 ug/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 4 publications below|
A novel gene associated with Retinoid-IFN-induced Mortality (GRIM) GRIM-19 gene was identified. Antisense expression of GRIM-19 confers a strong resistance against IFN/RA-induced death by reducing the intracellular levels of GRIM-19 protein. Overexpression of GRIM-19 enhances cell death in response to IFN/RA. GRIM-19 is primarily a nuclear protein whose expression is induced by the IFN/RA combination. These data indicate that GRIM-19 is a novel cell death-regulatory molecule.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
The transcriptional coregulator PGC-1ß controls mitochondrial function and anti-oxidant defence in skeletal muscles.
43-9200 was used in western blot to find the function of transcriptional coregulator PGC-1beta in mitochondria and anti-oxidant defense in skeletal muscles
|Gali Ramamoorthy T,Laverny G,Schlagowski AI,Zoll J,Messaddeq N,Bornert JM,Panza S,Ferry A,Geny B,Metzger D||Nature communications (6:null)||2015|
Prevention and reversal of severe mitochondrial cardiomyopathy by gene therapy in a mouse model of Friedreich's ataxia.
43-9200 was used in western blot to assess the use of gene therapy in treating Friedreich's ataxia cardiomyopathy in a mouse model.
|Perdomini M,Belbellaa B,Monassier L,Reutenauer L,Messaddeq N,Cartier N,Crystal RG,Aubourg P,Puccio H||Nature medicine (20:542)||2014|
|Human||1:2000||The expression of nicotinamide N-methyltransferase increases ATP synthesis and protects SH-SY5Y neuroblastoma cells against the toxicity of Complex I inhibitors.||Parsons RB,Aravindan S,Kadampeswaran A,Evans EA,Sandhu KK,Levy ER,Thomas MG,Austen BM,Ramsden DB||The Biochemical journal (436:145)||2011|
|Human||Not Cited||Identification of alternatively spliced GRIM-19 mRNA in kidney cancer tissues.||He X,Cao X||Journal of human genetics (55:507)||2010|