MA5-17133 targets NEDD8 in FACS, ICC, IHC, IF and WB applications and shows reactivity with Human samples.
The MA5-17133 immunogen is purified recombinant fragment of human NEDD8 expressed in E. Coli.
MA5-17133 detects NEDD8 which has a predicted molecular weight of approximately 9kDa.
Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.Tissue specificity: Highly expressed in heart, skeletal muscle, spleen, thymus, prostate, testis, ovary, colon and leukocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: NEDD-8; NEDD8; Neddylin; Neural precursor cell expressed developmentally down-regulated protein 8; Ubiquitin-like protein Nedd8
Gene Aliases: NEDD-8; NEDD8
UniProt ID: (Human) Q15843
Entrez Gene ID: (Human) 4738