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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide: L(164) R A E S E V K K Q K G R M L G(177)|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-4304 detects the human NEI3 protein in human samples.
PA1-4304 has been successfully used in Western blot procedures. By Western blot this antibody detects a ~68 kDa protein representing NEI3 in human testis lysate.
PA1-4304 immunizing peptide corresponds to amino acid residues 164-177 of the human NEI3 protein. There is 85% sequence identity to mouse and rat.
Prokaryotes and lower eukaryotes possess redundant activities that remove the plethora of oxidative DNA base damages produced during normal oxidative metabolism and which have been associated with cancer and aging. Thus far, only one oxidized pyrimidine-specific DNA glycosylase has been identified in humans, hNthl. HNEI3 is one of three new putative human DNA glycosylases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
DNA glycosylase FPG2; DNA glycosylase hFPG2; DNA glycosylase/AP lyase Neil3; endonuclease VIII-like 3; FGP2; FLJ10858; FPG2; hFPG2; hNEI3; nei endonuclease VIII-like 3; nei-like DNA glycosylase 3; nei-like protein 3; NEI3; zinc finger, GRF-type containing 3
FGP2; FPG2; hFPG2; hNEI3; NEI3; NEIL3; ZGRF3