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|Tested species reactivity||Human, Mouse, Rat|
|Published species reactivity||Rat, Mouse|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Synthetic peptide corresponding to amino acids 526-539 (GLLSGDEDFSSIAD) of human NF-kB (p65) protein.|
|Contains||0.05% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||0.25-0.5 µg/10^6 cells|
|Immunohistochemistry (IHC)||5-15 µg/ml|
|Immunohistochemistry (Paraffin) (IHC (P))||5 µg/ml|
|Western Blot (WB)||2-5 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (IHC)||See 5 publications below|
Suggested positive control: antigen standard for NFKB1 (transient overexpression lysate), Ramos, Daudi, HeLa, NIH-3T3.
NF-kB (nuclear factor kB) regulates the expression of a large number of genes that play critical roles in apoptosis, viral replication, tumorigenesis, various autoimmune diseases and inflammation. The active nuclear form of the NF-kB transcription factor complex is composed of two DNA binding subunits, NF-kB p65 and p50, both of which share extensive N-terminal sequence homology with the v-rel oncogene product. N-terminal regions of p50 and p65 are critical for DNA binding and help determine the DNA-binding specificities of p50 and p65.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Hepatoprotective effect of coenzyme Q10 in rats with acetaminophen toxicity.
MA5-16160 was used in immunohistochemistry to investigate the protective effect of coenzyme Q10 against acetaminophen toxicity in rat liver
|Fouad AA,Jresat I||Environmental toxicology and pharmacology (33:158)||2012|
Rutin attenuates cisplatin induced renal inflammation and apoptosis by reducing NFκB, TNF-α and caspase-3 expression in wistar rats.
MA5-16160 was used in immunohistochemistry to investigate the mechanism for the protective effect of rutin on inflammation and cell death
|Arjumand W,Seth A,Sultana S||Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association (49:2013)||2011|
Protective effect of telmisartan against cadmium-induced nephrotoxicity in mice.
MA5-16160 was used in immunohistochemistry to investigate the protective effect of telmisartan against cadmium nephrotoxicity
|Fouad AA,Jresat I||Life sciences (89:29)||2011|
Ameliorative effects of telmisartan in diabetic rats with indomethacin-induced gastric ulceration.
MA5-16160 was used in immunohistochemistry to investigate the potential therapeutic application of telmisartan in diabetes treatment
|Fouad AA,Al-Sultan AI,Yacoubi MT,Gomaa W||European journal of pharmacology (637:162)||2010|
Coenzyme Q10 treatment ameliorates acute cisplatin nephrotoxicity in mice.
MA5-16160 was used in immunohistochemistry to investigate the protective effect of Coenzyme Q10 against cisplatin nephrotoxicity in mice
|Fouad AA,Al-Sultan AI,Refaie SM,Yacoubi MT||Toxicology (274:49)||2010|
avian reticuloendotheliosis viral (v-rel) oncogene homolog A; NF-kappa-B p65delta3; NF-kappa-B transcription factor p65; NFKB3; nuclear factor kappa B subunit p65; nuclear factor NF-kappa-B p65 subunit; nuclear factor of kappa light polypeptide gene enhancer in B-cells 3; p65 NF kappaB; p65 NF-kappa B; p65 NFkB; transcription factor p65; v-rel avian reticuloendotheliosis viral oncogene homolog A; v-rel reticuloendotheliosis viral oncogene homolog A
NFkB; NFKB3; p65; RELA