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Abnova
NFRKB Monoclonal Antibody (3G8)
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Product Details
H00004798-M03
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
3G8
Immunogen
NFRKB (NP_006156, 90 a.a. approximately 197 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Immunogen sequence: FPEDSAEQQN ELILALFSGE NFRFGNPLHI AQKLFRDGHF NPEVVKYRQL CFKSQYKRYL NSQQQYFHRL LKQILASRSD LLEMARRSGP ALPFRQKRPS PSRTPEER
Target Information
NFRKB (nuclear factor related to kappa-B-binding protein) was first identified as a factor that could bind a variant NF-kappa B site in the interleukin-2 receptor alpha (IL-2R alpha) gene. NFRKB appears to be a transcription factor central to immune cell development. Evidence of this comes from the identification of NFRKB as an amplified gene in several cases of acute myeloid leukemia. Additionally, in another clinical case, a partial deletion of the chromosomal region that includes NFRKB is shown to be associated with combined cellular immunodeficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DNA-binding protein R kappa B; INO80 complex subunit G
Gene Aliases: INO80G
UniProt ID: (Human) Q6P4R8
Entrez Gene ID: (Human) 4798
telomere maintenance
regulation of DNA replication
regulation of DNA repair
chromatin remodeling
regulation of chromosome organization
positive regulation of DNA repair
positive regulation of transcription, DNA-templated
regulation of embryonic development
regulation of DNA metabolic process
regulation of cell cycle
regulation of DNA strand elongation
positive regulation of telomere maintenance in response to DNA damage
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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