PA5-16758 targets NFkappaB/p65 in IHC (P) and WB applications and shows reactivity with Human, Rabbit, and Rat samples.
The PA5-16758 immunogen is a synthetic peptide corresponding to internal domain of human NFkappaB p65.
NFkappaB is a heterodimer consisting of a 50kDa DNA binding subunit and a 65kDa transactivating subunit (RelA). The p50/p65 heterodimer is present in the cytoplasm in inactive form bound to its inhibitor, IkappaB. In unstimulated cells, nuclear localization signals present on p65 are masked by members of the IkappaB family of inhibitory proteins. Subsequent to cell stimulation, IkappaB undergoes phosphorylation, ubiquitination and degradation by a proteosome-dependent pathway, allowing nuclear translocation of the active dimeric NFkappaB transcription factor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: NF-kappa-B p65delta3; NF-kappa-B transcription factor p65; nuclear factor kappa B subunit p65; Nuclear factor NF-kappa-B p65 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3; Transcription factor p65; v-rel avian reticuloendotheliosis viral oncogene homolog A; v-rel avian reticuloendotheliosis viral oncogene homolog A (nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 (p65)); v-rel reticuloendotheliosis viral oncogene homolog A
Gene Aliases: NFkB; NFKB3; p65; RELA
UniProt ID: (Human) Q04206