Reactivity: ABS 062-14-02 binds human NGAL coated onto a solid phase. ABS 062-14-02 can be used as a detection antibody in a sandwich ELISA with capture antibodies HYB 211-01-02, ABS 038-04-02, ABS 038-14-02, ABS 038-15-02, ABS 038-23-02, ABS 038-26-02 and ABS 062-33-02. When ABS 062-14-02 is used as a biotinylated detection antibody with capture antibody ABS 062-33-02, the assay is specific for the NGAL monomer, cross-reacting less than 1% with NGAL homodimer.
NOTE: Concentration is lot-dependent and can vary from 0.85-1.15 mg/mL
NGAL (Neutrophil gelatinase-associated lipocalin, lipocalin 2, siderocalin and neutrophil lipocalin) is a 25 kDa glycosylated single chain monomer and member of the lipocalin family of proteins that bind and transport small lipophilic molecules. NGAL is released by activated neutrophils, can form dimers and small amounts of higher oligomers, and complexes with matrix metalloproteinase 9 (MMP-9, gelatinase B). Low level expression of NGAL in a variety of epithelia may be increased in inflammation or cancers. Expression of NGAL in the kidney is dramatically increased by ischemic or nephrotoxic kidney injury.
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Protein Aliases: 25 kDa alpha-2-microglobulin-related subunit of MMP-9; HGNC:6526; Lipocalin-2; Lipocalin2; migration-stimulating factor inhibitor; Neutrophil gelatinase-associated lipocalin; NGAL; Oncogene 24p3; OTTHUMP00000022240; p25; RP23-161B9.11; Siderocalin; siderocalin LCN2; uterocalin
Gene Aliases: 24p3; HNL; LCN2; MSFI; NGAL; p25
UniProt ID: (Human) P80188
Entrez Gene ID: (Human) 3934