In IHC applications, this antibody is suitable for use in paraformaldehyde-fixed, alcohol-fixed and paraffin-embedded sections.
Reconstitute in 100 µL of sterile water.
Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with NGFRAP1/BEX3. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CD271; Gp80-LNGFR; L; low affinity nerve growth factor receptor; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor; nerve growth factor receptor (TNFR superfamily, member 16); nerve growth factor receptor, fast; NGF receptor; Ngfr; p-75; p75 ICD; Tnfrsf16; TNR16; Tumor necrosis factor receptor superfamily member 16
Gene Aliases: LNGFR; Ngfr; p75; p75NTR; RNNGFRR; Tnfrsf16
UniProt ID: (Rat) P07174
Entrez Gene ID: (Rat) 24596